Comparing the anti-arthritic activities of the plants Justicia gendarussa Burm F. and Withania somnifera Linn
DOI:
https://doi.org/10.22377/ijgp.v3i4.101Abstract
The aim of this study was to compare the anti-arthritic activities of the plants Justicia gendarussa and Withania somnifera. Arthritisis induced in male albino rats using Freund’s complete adjuvant and bovine type II collagen. Leaves of J. gendarussa and roots of
W. somnifera were powdered and extracted with ethanol (95%) using the soxhlet method. The effect of these plant extracts on
arthritic rats were assessed by various blood parameters and also by taking the change in paw volume. The plants J. gendarussa and
W. somnifera suppressed the anti-arthritic changes induced in rats and the results were statistically significant.
Key words: Arthritis, collagen, paw volume, plant extract
Downloads
References
Abhyankar GA, Chinchanikar GS. Response of Withania somnifera
Dunal leaf explants in vitro. Phytomorphology 1996;46:249-52.
Amara S, Prasanna Kumar S, Athota RR. Suppressive effect of
Withania somnifera root extract on the induction of anti-ovalbumin
IgE antibody response in mice. Pharmaceut Biol 1999;37:253-9.
Corrilo M, Ciampa G. Paper chromatography of Withania somnifera
alkaloid. J Chromatogr ;3:291-2.
Sastri BN. Wealth of India: Raw materials. Vol. 5, Council of
Scientific and Industrial Research, New Delhi: 1959. p. 312-3.
Jayasinghe DM. Ayurveda Pharmacopeia, Department Ayurveda,
Colombo, Sri Lanka: 1979. p. 30-2.
Newbould BB. Chemotherapy of arthritis induced in rats by
Mycobacterial adjuvant. Br J Pharmacol 1963;21:127-36.
Mizushima Y, Tsukada W, Akimoto T. A modification of rat
adjuvant arthritis for testing antirheumatic drugs. J Pharm
Pharmacol 1972;24:781-5.
Anthony DD, Haqqi TM. Collagen-induced arthritis in mice: An
animal model to study the pathogenesis of rheumatoid arthritis.
Clin Exp Rheumatol 1999;17:240-4.
Austin JH, Drabkin DL. Estimation of haemoglobin. J Biol Chem
;12:67.
Chesbrough M, McArthur J. Laboratory manual of rural tropical
hospitals. The English Language Book Society and Churchill
Livingstone: 1972. p. 145.
David G, Sykes AJ. Westergren and Wintrobe methods of
estimating ESR compared. Br Med J 1951;2:1496-7.
Landers JP. Handbook of capillary electrophoresis. Danvers, USA:
CRC Press LLC; 2nd ed. 1996. p. 567-90.
Taneja V, Taneja N, Paisansinsup T, Behrens M, Griffiths M,
Luthra H, et al. CD4 and CD8 T cells in susceptibility/protection
to collagen-induced arthritis in HLA-DQ8-transgenic mice:
Implications for rheumatoid arthritis. J Immunol 2002;168:5867-75.
Feldmann M, Brennan FM, Maini RN. Role of cytokines in
rheumatoid arthritis. Annu Rev Immunol 1996;14:397-440.
Begum VH, Sadique J. Long term effect of herbal drug Withania
somnifera on adjuvant induced arthritis in rats. Indian J Exp Biol
;26:877-82.
Glen EM, Bowman BJ, Ronloff NA, Seely RJ. A major contributory
cause of arthritis in adjuvant inoculated rats: Granulocytes. Agents
Actions 1977;7:265-82.
Allar S, O’Driscoll J, Laurie A. Salmonella osteomyelitis in aplastic
anaemia after anti-lymphocytic globulin and steroid treatment.
J Clin Pathol 1977;2:174-5.
Mowat G. Haematological abnormalities in rheumatoid arthritis.
Semin Arthritis Rheum 1971;1:195-9.
McConkey B, Crockson RA, Crockson AP, Nilkinson AR. The effect
of some anti inflammatory drugs on the acute-phase proteins in
rheumatoid arthritis. Q J Med 1973;32:785-91.
Revnic F. The significance of serum ceruloplasmin in diagnosis of
rheumatoid arthritis. Toxicol Lett 1995;78:70.
White AG, Scudder P, Dormandy L, Martin VM. Copper-an index
of erosive activity? Rheumatology 1978;17:3-5.
Wahi SP, Wahi AK, Kapoor R. Chemical study of the leaf of Justicia
gendarussa Burm. JRIM 1974;9:65-6.
Bhutani KK, Gupta DK, Kapil RS. A process for the isolation of
bioactive peptide fraction from the plant W. somnifera. 1994; Indian
Patent No.1195/DEL/94 DT.23.9.94
Davis L, Kuttan G. Suppressive effect of cyclophosphamideinduced
toxicity by Withania somnifera extract in mice. J Ethno
Pharmacol 1998;62:209-14.
Dhuley JN. Effect of ashwagandha on lipid peroxidation in stress
induced Animals. J Ethano Pharmacol 1998;60:173-8.
Gupta AP, Verma RK, Mishra HO, Gupta MM. Quantitative
determination of Withaferin A in different plant parts of
Withania somnifera by TLC densitometry. J Med Aromat Plant Sci
;18:788-90.
Kulkarni RR, Patki PS, Jog VP, Gandage SG, Patwardhan B.
Treatment of osteoarthritis with a herbo mineral formulation:
A double-blind, placebo-controlled, cross-over study.
J Ethnopharmacol 1991;33:91-5.