A preliminary study on hypolipidemic effect of aqueous leaf extract of Clerodendron glandulosum.Coleb
DOI:
https://doi.org/10.22377/ijgp.v3i4.102Abstract
Aqueous extract of Clerodendron glandulosum. Coleb (CG) (400 mg/kg/day) was orally administered to rats rendered hyperlipidemic chronically (by feeding high-fat diet; HL) to assess its possible lipid-lowering potential. The hyperlipidemic rats were administered CG extract by oral gavage from 30-90 days along with high fat diet. Plasma lipid profile was monitored on 30th, 60th and 90th days to assess the effect of CG extract. Observations revealed a decrement in body weight (9.6%), plasma TC (15.63%), TG (42.99%), PL (13.91%),LDL-C (81.36%) and VLDL-C (43%) along with an increase in HDL-C (52.84%) at 90 days (after 60 days of CG extract feeding)
compared to high levels at 30 days. Fecal lipid analysis revealed high content of TC, TG and PL in HL 1 CG group. Lipid‑lowering
property of the CG extract in chronic hyperlipidemic rats validates its use traditionally as a part of folklore medicine in North-eastern India, though there is no scientific evaluation to date.
Key words: Cholesterol, Clerodendron glandulosum. Coleb, hyperlipidemia, lipoproteins
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