Hemidesmus indicus root extract ameliorates diabetes-mediated metabolic changes in rats

Authors

  • Gayathri Mahalingam
  • Krishnan Kannabiran

DOI:

https://doi.org/10.22377/ijgp.v3i4.108

Abstract

India has more than 40 million diabetic people that represent nearly 20% of total diabetes population worldwide. Allopathic medicines are currently used for control of diabetes but often they are overprescribed or found to be dangerous on long-term use due to its toxicity and side effects. Plant-based remedies remain to be one of the most popular complementary treatments for diabetes mellitus and are considered to be natural and comparatively safe. Traditionally, many plants are used in Ayurveda, Sidha and folklore systems
of medicines to treat diabetes mellitus, but the pharmacognostic and pharmacological studies on many of these plants are yet to be performed. Hence, the present study aims to explore the anti-diabetic activity of Hemidesmus indicus roots in streptozotocin-induced diabetic rats. The oral administration of aqueous extract at doses of 500 mg/kg significantly reduced the blood glucose within 5 h and 12-week treatment reverted the altered levels of insulin, glycosylated hemoglobin, total cholesterol, HDL-cholesterol, LDL-cholesterol,
triglycerides, alkaline phosphatase (ALP), aspartate transaminase (AST), alanine transaminase (ALT), g-glutamyl transferase (g—GT) and creatine kinase (CK) to near normal levels in diabetic rats. The results of the present study suggest that H. indicus administration not only reduces blood glucose but also offers protection to diabetes-induced metabolic alterations in rats.
Key words: Diabetes mellitus, Hemidesmus indicus, metabolic changes, streptozotocin

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References

Zimmet P, Albertu KG, Shaw J. Global and societal implications

of the diabetes epidemic. Nature 2001;414:782-7.

World Health Organization Consultation, Definition, diagnosis

and classification of diabetes mellitus and its complications. Part I:

Diagnosis and classification of diabetes mellitus, Report of a WHO

Consultation. Geneva: 1999.

Cheng AY, Fantus GI. Oral antihyperglycemic therapy for type 2

diabetes mellitus. Canadian Med Assoc J 2005;172:213-26.

Grover JK, Yadav S, Vats V. Medicinal plants of India with antidiabetic

potential. J Ethnopharmacol 2002;81:81-100.

Swanston-Flatt SK, Flatt PR, Day C, Bailey CJ. Traditional dietary

adjuncts for the treatment of diabetes mellitus. Proc Nutr Soc

;50:641-51.

Srinivasan K. Plant foods in the management of diabetes mellitus:

Spices as beneficial antidiabetic food adjuncts. Int J Food Sci Nutr

;56:399-414.

Subash Babu P, Prabuseenivasan S, Ignachimuthu S.

Cinnamaldehyde: A potential antidiabetic agent. Phytomedicine

;14:15-22.

Nadkarni AN. Indian Materia Medica, Vol. 1. Popular Book Depot,

Bombay, India, 1989. p. 619.

Jain A, Basal E. Inhibition of Propionibacterium acnes-induced

mediators of inflammation by Indian herbs. Phytomedicine

;10:34-8.

Kirtikar KR, Basu BD. Indian medicinal plants. In: Basu LM, editor.

Deharadun: 1991. p. 1593-1598.

Shetty TK, Satav JG, Nair CK. Radiation protection of DNA and

membrane in vitro by extract of Hemidesmus indicus. Phytother Res

;19:387-90.

Jain SP, Singh SC. Ethno-medico-botanical survey of Ambikapur

District, MP. Fourth International Congress of Ethnobiology, NBRI,

Lucknow, UP, India: 1994.

Alam MI, Gomes A. Viper venom-induced inflammation and

inhibition of free radical formation by pure compound (2- hydroxy-

-methoxy benzoic acid) isolated and purified from anantamul

(Hemidesmus indicus R. BR) root extract. Toxicon 1998;36:207-15.

Saravanan N, Rajashankar S, Nalini N. Antioxident effect

of 2-hydroxy-4-methoxy benzoic acid on ethanol induced

hepatotoxicity in rats. Pharma Pharmacol 2007;59:445- 53.

Baheti JR, Goyal RK, Shah GB. Hepatoprotective activity of

Hemidesmus indicus R.br. in rats. Indian J Exp Biol 2006;44:399- 402.

Nagarajan L. Jagan Mohan Rao KN, Gurudutt. Chemical

composition of the volatiles of Hemidesmus indicus. R.Br. Phytother

Res 2001;16:212-4.

Gayathri M, Kannabiran K. Hypoglycemic activity of

Hemidesmus indicus R. Br. on streptozotocin induced diabetic

rats. Int J Diab Dev Ctries 2008;28:6-10.

Sarkar S, Pranava M, Marita RA. Demonstration of the

hypoglycemic action of Momordica charantia in a validated animal

model of diabetes. Pharmacol Res1996;33:1-4.

Drabkin DL, Austin JM. Spectrophotometric studies,

spectrophotometric constants for common haemoglobin

derivatives in human, dog and rabbit blood. J Biol Chem

;98:719-33.

Bannon P. Effect of pH on the elimination of the labile fraction of

glycosylated hemoglobin. Clin Chem 1982;28:2183.

Ayba M, Sanchez RA, Grau A, Sanchez SS. Hypoglycemic effect of

the water extract of Smallanthus soncifolius (yacon) leaves in normal

and diabetic rats. Br J Ethnopharmacol 2002;74:125-32.

Pari L, Maheswari UJ. Antihyperglycemic activity of Amausa

sapientum flowers: Effect on lipid peroxidation in alloxan diabetic

rats. Phytother Res 2000;14:136-8.

Stanley P, Prince M, Menon VP. Hypoglycemic and other related

actions of Tinospora cordiifilo in alloxan-induced diabetic rats. Br J

Ethnopharmacol 2000;70:9-15.

Banerjee M, Bhonde R. Islet generation from intra islet precursor

cells of diabetic pancreas: In vitro studies depicting in vivo

differentiation. J Pancreas 2003;4:137-45.

Dor Y, Brown J, Martinez OI, Melton DA. Adult pancreatic

beta-cells are formed by self-duplication rather than stem cell

differentiation. Nature 2004;429:41-6.

Vats V, Yadav SP, Grover JK. Ethanolic extract of Ocimum sanctum

leaves partially attenuates streptozotocin induced alterations

in glycogen content and carbohydrate metabolism in rats.

Br J Ethnopharmacol 2004;90:155-60.

Golay A, Munger R, Jennet FA, Harsh EB, Habicht F, Felber JP.

Progressive defect of insulin action on glycogen synthase in obesity

and diabetes. Metabolism 2002;51:549-53.

Prakasam A, Sethupathy S, Pugalendi KV. Influence of Casearia

esculenta root extract on protein metabolism and marker enzymes

in streptozotocin-induced diabetic rats. Polisch J Pharmacol

;56:587-93.

Babu PV, Sabitha KE, Srinivasan P, Shyamaladevi CS. Green

tea attenuates diabetes induced Maillard-type fluorescence and

collagen cross-linking in the heart of streptozotocin diabetic rats.

Pharmacol Res 2007;55:433-40.

Ohaeri OC. Effect of garlic oil on the levels of various enzymes

in the serum and tissue of streptozotocin diabetic rats. Biosci Rep

;21:19-24.

Chaude MA, Orisakwe OE, Afonne OJ, Gamenial KS, Vongtau OH,

Obi E. Hypoglycemic effect of the aqueous extract of Boerrhavia

diffusa leaves. Indian J Pharmacol 2001;33:215-6.

Prince PS, Menon VP, Pari L. Effect of Syzigium cumini extracts on

hepatic hexokinsae and glucose 6- phosphatase in experimental

diabetes. Phytother Res 1997;11:529-31.

Shanmugasundaram K, Panneerselvam C, Saumudaram P,

Shanmugasundaram ER. Enzyme changes and glucose utilization

in diabetic rabbits: The effect of Gymnema sylvestrae R. Br

J Ethnopharmacol 1983;7:205-34.

Source of Support: Nil, Conflict of Interest

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