Hypoglycemic effect of Swietenia macrophylla seeds against type II diabetes
DOI:
https://doi.org/10.22377/ijgp.v2i4.11Abstract
Th e antidiabetic eff ect of Swietenia macrophylla seeds was evaluated in Streptozotocin and Nicotinamide induced type II diabetic rats. Methanol extract of Swietenia macrophylla seeds was administered orally at doses of 150 and 300 mg/kg body weight for 12 consecutive days. Fasting blood sugar (FBG) was estimated on overnight fasted rats on day 1, 5 and 12 days. Lipid profi les, liver glycogen levels and changes in body weight were also measured. Th e extract was found more eff ective at the dose of 300 mg/kg body weight and it lowered FBG levels was statistically signifi cant P < 0.01 (32.78%) in diabetic rats at day 12. Extract at the same dose also signifi cantly reduced P < 0.01 the elevated level of serum total cholesterol (18.56%) and triglyceride (10.41%), and increased P < 0.01 (46.27%) thereduced liver glycogen level. Th ough statistically non-signifi cant the extract at both the doses was found to improve the body weight of diabetic rats. Th e observation concludes that the methanol extract of seeds of Swietenia macrophylla has hypoglycemic as well as hypolipidemic eff ect.
Key words: Swietenia macrophylla, Streptozotocin, Nicotinamide, type II diabetes
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