Evaluation of the effectiveness of complex therapy with the inclusion of a prebiotic in children with non-alcoholic fatty liver disease and excess body weight

Abstract

Aim: The present study aimed to evaluated the effectiveness of complex therapy of non-alcoholic fatty liver disease (NAFLD) with the inclusion of prebiotic lactulose on the functional state of the liver, biliary tract, intestinal microbiota, lipid and carbohydrate metabolism in 54 adolescents with excess body weight and insulin resistance (IR). Materials and Methods: The diagnosis of NAFLD was established based on the accepted criteria of ultrasound examination. Result and Discussion: Ultrasound criteria typical for liver steatosis were detected in 48% of cases, along with signs of steatosis of the pancreas and violations of the motor function of the biliary tract in 70% of patients. Conclusion: It has been shown that the combination of prebiotic with insulin sensitizer metformin contributes to a greater decrease in body weight, in the manifestations of steatosis of the liver and pancreas, normalization of the state of the intestinal microbiota, a decrease in IR, a level of triglycerides compared to monotherapy with metformin