Preliminary phytochemical and antiulcer studies of Hibiscus rosa sinensis Linn. root extracts
DOI:
https://doi.org/10.22377/ijgp.v4i1.117Abstract
The antiulcer activity of various extracts of Hibiscus rosa sinensis roots was evaluated in pyloric ligation induced gastric ulcer in albino rats. The root extracts were prepared by cold maceration process with petroleum ether, alcohol and water separately. The preliminary phytochemical screening of H. rosa sinensis revealed the presence of sterols, glycosides, proteins, mucilage and flavonoids. Oral administration of aqueous and alcohol extracts (250 and 500 mg/kg) of H. rosa sinensis roots were evaluated for antiulcer activity and compared with the standard drug, lansoperazole (8 mg/kg). From the results, it can be concluded that the aqueous extract of H. rosa sinensis roots (500 mg/kg) showed highly significant (P<0.001) dose-dependent antiulcer activity. These results lend scientificsupport for the plant as folk medicine.
Keywords: Hibiscus rosa sinensis, antiulcer activity, pyloric ligation, maceration
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References
Chatterjee A, Pakrashi SC. The Treatise of Indian medicinal plants.
p. 180.
Chopra RN, Chopra IC, Varma BS. Supplementary to glossary of
Indian medicinal plants. New Delhi: India; 1969. p. 39.
Shimizu N, Tomoda M, Suzuki I, Takada K. Plant mucilages XLIII.
A representative mucilage with biological activity from the leaves
of Hibiscus rosa sinensis. Biol Pharm Bull 1993;16:735-9.
Sharma UD. Cure of heart diseases with ayurvedic drugs. Sacitra
Ayurveda 1994;47:95-6.
Reddy CM, Murthy DR, Patil SB. Antispermatogenic and
androgenic activities of various extracts of Hibiscus rosa sinensis
in albino mice. Indian J Exp Biol 1997;35:1170-4.
Serrame E, Lim SCY. Antitumour promoting activity of decoctions
and expressed juices from Philippine medicinal plants. Philipine
J Sci 1995;124:275-81.
Kasture VS, Chopde CT, Deshmukh VK. Anticonvulsive activity
of Albizzia lebbeck, Hibiscus rosa sinensis and Butea monosperma in
experimental animals. J Ethnopharmacol 2000;71:65-75.
Alam MM, Siddiqui MB, Hussain W. Treatment of diabetes
through herbal drugs in rural India. Fitoterapia 1990;61:240-2.
Ali M, Ansari SH. Hair care and herbal drugs. Ind J Nat Prods
;13:3-5.
Nadkarni AK. Indian Materia Medica. Bombay: 1954. p. 631.
Anbu Jeba Sunilson J, Anita GKAV, Jisha J, Varatharajan R, Jayaraj
P, John T. Formulating and screening of herbal wound healing
ointment. Adv Pharmacol Toxicol 2008;2:41-5:1-7.
Anbu Jeba Sunilson J, Muthu MS, Syam MM, Anita GKAV, John T,
Jayaraj P. Antidiabetic activity of Momordica tuberose Roxb. COGN.
Tuber extracts. Int J Pharmacol Biol Sci 2008;9:41-5.
Suma V, Swamy MM, Vijayalakshmi S, Reddy YSR, Suresh B.
Pharmacognostical observations on Sida Rhomboidea Roxb-A report.
Ind Drugs 1994;31:421-5.
Anshurathi Rao Ch V, Khatoon S, Mehrotra S. Ethno
pharmacological evaluation of Peristrophe bicalyculata Nees antiinflammatory
and analgesic activity. Nat Prod Sci 2003;9:195-9.
Zimmermann M. Ethical guidelines for investigations of
experimental pain in conscious animals. Pain 1983;16:109-10.
Anbu Jeba Sunilson J, Varatharajan R, John T, Jayaraj P, Jisha J,
Proomwichit P. Gastroprotective and antioxidant activities of the
roots of Hibiscus aculeatus Roxb. Int J Pharmacol 2008;4:1-6.
Deshpande SS, Shah GB, Parmar NS. Antiulcer activity of Tephrosia
purpurea in rats. Ind J Pharmacol 2003;35:168-72.
Devendra S, Tushar P, Samaresh PR, Jyothi TM, Rajendra SV,
Prabhu K, et al. Anti-ulcer properties of 70% alcoholic extract of
leaves of Albizzia lebbeck. Phcog Mag 2008;4:228-31.
Tan PV, Nditafon NG, Yewah MP, Dimo T, Ayafor FJ. Eremomastax
speciosa: effects of leaf aqueous extract on ulcer formation and
gastric secretion in rats. J Ethnopharmacol 1996;54:139-42.
Kulkarnai SK. Handbook of experimental pharmacology. New
Delhi; India: Vallabh Prakashan; 1999. p. 172.
Jadhav RB, Sonawane DS, Surana SJ. Cytoprotective effects of
crude polysaccharide fraction of Abelmoschus esculentus fruits in
rats. Phcog Mag 2008;4:130-2.
Erdem Y, Yoshihisa T. A saponin with anti-ulcerogenic e€ect from
the flowers of Spartium junceum. Phytochemistry 1999;51:903-8.
Aguwa CN, Nwanko SO. Preliminary studies on the root extract of
Naulea latifolia Smith, for antiulcer properties. Nig J Pharmaceutical
Sci. 1988;4:16-23.
John TA, Onabanjo AO. Gastroprotective effect of an aqueous
extract of Entandro phragmautile bark in experimental ethanolinduced
peptic ulceration in mice and rats. J. Ethnopharmacol.
;29:87-93.
Dahiru D, Onubiyi JA, Umaru HA. Phytochemical screening and
antiulcerogenic effect of Moringa oleifera aqueous leaf extract. Afr
J Trad Comp Alt Med. 2006;3:70-5.
