Pharmacotherapeutic efficiency of the new complex urological herbal medicine in experimental urolithiasis

Abstract

Purpose: The purpose of this study is to determine pharmacotherapeutic efficacy of complex urological herbal medicine on the course of experimental urolithiasis in laboratory animals. Methods: Experiments were carried out on white Wistar rats. Urolithiasis was reproduced by Higgens method by intragastric administration of Vitamin D2. Pharmacotherapeutic efficiency of aqueous extract of complex urological herbal remedy was determined using well-known methods of analysis. Results: Course administration of complex urological herbal remedy in experimental therapeutic dose of 10 mL/kg against the background of experimental urolithiasis has pronounced pharmacotherapeutic effect. It helps to normalize the morphofunctional state of the laboratory animals’ kidneys at the stages of pathological process in comparison with the data in the control group of animals. Conclusion: New complex urological herbal remedy has a wide spectrum of pharmacological activity, which provides its pronounced pharmacotherapeutic efficacy in experimental urolithiasis. It is promising to develop methodological recommendations on the use of the developed herbal medicine in clinical practice for the treatment and prevention of urolithiasis.