Advancement in sandhana kalpana and role of biotechnology: Need of research for diabetic patients

Abstract

The diabetic population of India is increasing day by day. At the meantime, diabetic patients also adopt ayurvedic treatment for their other chronic ailments. Sandhana Kalpana, which deals with hydroalcoholic oral dosage form, has a number of formulations for various ailments in ayurvedic treasures. However, ayurvedic practitioners failed to prescribe this dosage form to the diabetic patients because of more percentage of sugar content in asava-arishta. Hence, there is need to replace jaggery from other carbohydrate sources, namely, starch and cellulosic material which produce less sugar percentage in asava-arista. As Saccharomyces cerevisiae directly ferment the sugar molecule into alcohol, but starchy and cellulosic feedstocks required specific treatment, before the fermentation process. Different researchers have been done which revealed that uses of engineered strains are helpful in direct production of alcohol. Therefore, it is required to change the feedstock and, respectively, the strain of yeast. Schwanniomyces castellii and Endomycopsis fibuligera are some of the available strains of yeast which when used with can transform the starch directly into alcohol. Further, researchers are needed to manufacture asava-arishta from these first and second generation feedstocks with the care that therapeutic value should not to be altered.