Methodology of demand study for proton pump ingibitors drugs

Abstract

Aim: This study aims to describe the method and practical application of flexible tools for development of non-standard designs of selection models, implemented in the SAS system. The main research task was to study the demand for proton-pump inhibitors drugs (PPIs) that are prescribed for the treatment of gastric ulcer and duodenal ulcer. The difficulty was in the a priori present dependence on the choice of alternative on the attributes of other alternatives in the choice set. the dependence of choosing an alternative from the presence of others in the selection network is also non-standard. Hence, if the desired drug is absent in the pharmacy chain, the patient must choose the next desired one from the available ones. All this requires non-standard approaches in the creation of design, and therefore, of the corresponding tools. Materials and Methods: LIMDEP/NLOGIT and Sawtooth software; toolbox SAS. Results and Discussion: There are five groups of PPI according to the active ingredient: Omeprazole, lansoprazole, rabeprazole, pantoprazole, and esomeprazole medications. Taking into account the possibility of quadratic effects of the price for the drug at the patient’s discretion, we have used three-level attributes of the price, which provide the assessment of both linear and quadratic price effects. In the capacity of the effectiveness of the selected treatment regimens of gastric disease, we have chosen the anatomical cicatrization of mucosa damage at week 4 of treatment, according to the published specialized researches. Conclusion: Increasing of the analytical capabilities of the choice modeling allows using more flexible designs.