Anti-ulcer potential of Oxystelma esculentum
DOI:
https://doi.org/10.22377/ijgp.v5i1.177Abstract
Oxystelma esculentum is a perennial twiner growing near water-logged areas in the Indian subcontinent. It is used traditionally in stomach ulcers. The present work deals with the investigation of anti-ulcer potential of O. esculentum. The plant was successively extracted with solvents of varying polarities, which served as the test extracts. Anti-ulcer effect was checked in Wistar rats using aspirin- and ethanol-induced acute ulcer models. The petroleum ether extract was found to possess the most effective anti-ulcer activity. This proves the traditional claim of the plant as an anti-ulcer drug. Phytochemical screening of this extract revealed the presence of important classes of compounds like cardenolides, flavonoids, phenolics, sterols and triterpenoids. This bioactivityguided phytochemical screening can guide further therapeutic investigations and isolation of pharmacologically active compoundsfrom Oxystelma esculentum.
Key words: Anti-ulcer, oxystelma esculentum, oxystelma secamone, periploca esculenta
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References
Guha DN, Bakshi BK. Flora of Murshidabad District, West Bengal,
India. Jodhpur: Scientific Publishers; 1984.
Kirtikar KR, Basu BD. Indian Medicinal Plants, Vol. 3. New Delhi:
M/S Periodical Experts; 1975.
Watt G. Dictionary of Economic Products of India, Vol. 5. New
Delhi: Periodical Experts; 1891.
Durairaj A, Mazumder UK, Gupta M, Ray SK. Effects of methanolic
extract of Oxystelma esculentum on diuresis and urinary electrolytes
excretion in rats. Iranian J Pharmacol Ther 2007;6:207-11.
Konturek SJ, Piastucki I, Brzozowski T, Radecki T, Dembinska-Kiec
A, Zmuda A. Role of prostaglandins in the formation of aspirininduced
gastric ulcers. Gastroenterology 1981;80:4-9.
Robert A, Nezamis JE, Lancaster C, Hanchar AJ. Cytoprotection
by prostaglandins in rats: Prevention of gastric necrosis produced
by alcohol, HCl, NaOH, hypertonic NaCl, and thermal injury.
Gastroenterology 1979;77:433-43.
Ganguli AK, Bhatnagar OP. Effect of bilateral adrenalectomy on
the production of restraint ulcers in the stomach of albino rats.
Can J Physiol Pharmacol 1973;51:748-50.
Feigl F. Spot Tests in Organic Analysis, 4th ed. London: Elsevier;
Fishcher R. Praktikum der Pharmakognosic, 3rd ed. Berlin: Springer
Verlag; 1952.
Geissman A. Modern Methods of Plant Analysis, Vol. 3. Berlin:
Springer Verlag; 1955.
Harborne JB. Phytochemical Methods, 2nd ed. London: Chapman
and Hall Ltd.; 1973.
List PH, Horhammer L. Hager Hand buch der pharmazeutischem
praxis, Band 1. Berlin: Springer Verlag; 1967.
Robinson T. The Organic Constituents of Higher Plants, their
Chemistry and Interrelationships. Minneapolis: Burgers
Publishing Company; 1964.
Davenport HW. Fluid produced by gastric mucosa during damage
by acetic and salicylic acids. Gastroenterology 1967;50:487-99.
Halliwell B. Free radicals in biology and medicine. Oxford:
Clarrandon; 1985.
Robert A. Cytoprotection by prostaglandins. Gastroenterology
;77:761-7.
Roger SC, Pihan G, Szabo S. Role of leukotrienes in the
pathogenesis of hemorrhagic gastric mucosal lesions induced by
ethanol or HCl in rats. Gastroenterology 1986;90:1797-81.
Konda Y, Sakamoto C, Nishisaki H, Nakano O, Baba S. Ethanol
stimulates pepsinogen by opening calcium channels of guinea pig
gastric chief cells. Gastroenterology 1991;100:17-24.
Karmeli F. Okone E. Gastric mucosal damage by ethanol
is mediated by substance P and prevented by ketotifen.
Gastroenterology 1991;100:1206-15.
Szabo S, Trierer JS, Brown A, Schnoor J. Early vascular injury and
increased vascular permeability in gastric mucosal injury caused
by ethanol in rats. Gastroenterology 1985;88:228-36.
Kauffman GL. Can the mechanisms of aspirin induced gastric
mucosal injury be justified? In: Toxicology and Experimental
models. New York: Pergamon Press; 1981. p. 281-5.
Horowitz MI. Gastrointestinal glycoproteins. In: The
glycoconjugates Vol. 1. New York: Academic Press; 1977. p.
-213.
Sinclair AJ. Free radical mediated gastric mucosal injury.
Gastroenterology 1990;30:114-8.
