Apium graveolens accentuates urinary Ca+2 excretions in experimental model of nephrocalcinosis
DOI:
https://doi.org/10.22377/ijgp.v5i2.184Abstract
Nephrocalcinosis (NC) is a state characterised by deposition of calcium phosphate or oxalate in the renal parenchyma due to different clinical conditions. Apium graveolens (Celery) is a popular vegetable added to salads and many cooked dishes, used in Chinese medicine to reduce high blood pressure and in Arabic medicine to relieve renal pains. To evaluate the effect of A. graveolens in reducing calcium deposits from renal parenchyma in rabbit models with induced NC by a large dose of oxalic acid. A. graveolens produced a significant reduction of blood urea nitrogen (5.7±0.05 vs 7.3±0.2) mmol/l, serum creatinine (87.2±0.63 vs 97.3±0.5) mmol/l and serum Na+ levels (136.8±0.2 vs 142.16±0.7) mmol/l with non-significant reduction in serum K+ (3.3±0.8 vs 3.8±0.03). There is a significant reduction in calcium deposition in renal parenchyma in comparison to the control group after ten days of treatment. A. graveolens showed a significant diuretic effect that accentuates the excretion of urinary calcium.Key words: Acetylenics, allantoins, nephrocalcinosis, Vitamin D intoxication
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References
Eriksson Y. Renal function tests. Dorland's Medical Dictionary.
RD Edition. Philadelphia: Churchill Livingstone; 2002. p. 421-2.
Christopher H, Edwin R, Chilver S, John A. Davidson's principles
and practice of Medicine.19th ed. Philadelphia: Churchill
Livingstone; 2004. p. 594-9.
Drach GW. Urinary lithiasis, camphil urology. New York: WB
Sanders Comp; 1998. p. 2085-100.
Leyva M. The role of dietary calcium in disease prevention. J Okla
State Med Assoc 2003;96:272-5.
David L, Hoffman E. The herbalist and version. Hopki's technology,
th ed. Stamford, Connecticut: Appleton and Lange, 1993.
Al-Jawad FH, Hoshi A. Diuretic effect of some medicinal
plants in treatment induced renal calculi. Iraqi J Med Sci
;2:132-7.
Corl AB, Ashwood ER. Tietiz text book of clinical chemistry. Vol.
New York: WB Sanders Comp; 1999. p. 1059-60.
Putt N, Fredrick A. Manual of histopathological staining methods.
New York: John Wilay and sons; 1972. p. 335.
de O G Mendonça C, Martini LA, Baxmann AC, Nishiura JL,
Cuppari L, Sigulem DM, et al. Effect of an oxalate load on
urinary oxalate excretion in ca+2 stone formation. J Ren Nutr
;13:39-46.
Tsi D, Tan BK. The mechanism underlying the hypocholesterolaemic
activity of aqueous celery extract, its fractions in genetically
hypercholesterolaemic RICO rats. Life Sci 2000 14;66:755-67.
Khaw KT, Bingham S, Welch A, Luben R, Wareham N, Oakes S,
et al. European prospective investigation into cancer and nutrition.
Lancet 2001;357:657-63.
Ensminger AH, Esminger MK. J. Food for Health: A Nutrition
Encyclopedia. Clovis, California: Pegus Press; 1986. PMID:
Smith LH. Urolithiasis. In: Schrier RW, Gottschalk CW. disease of
kidney. Philadelphia: WB Sanders Comp; 1996;1:785-813.
Ives HE. Diuretic agents. Basic and clinical pharmacology. In:
Katzung BG, Masters SB, Treven AJ, editors.11th International ed.
New York: McGraw Hill; 2010.
