Antimicrobial, cytotoxic and antidiarrhoeal activity of Fimbristylis aphylla L.
DOI:
https://doi.org/10.22377/ijgp.v5i2.192Abstract
This study was conducted to evaluate the antimicrobial, cytotoxic and antidiarrhoeal activity of Fimbristylis aphylla L methanolextract. Preliminary phytochemical screenings with the crude extractives demonstrated the presence of alkaloids, glycosides, saponins and reducing sugars. In the disc diffusion antimicrobial sensitivity test, the crude extractive of the whole plant produced moderate to strong antimicrobial activity against the test microorganisms. The zone of inhibition was found within the range of 10.33–15.33 mm. The strongest zone of inhibition was found against Shigella dysenteriae. The extractive was found active against only a few number of test pathogens. In the cytotoxicity test by brine shrimp lethality bioassay, the extract exhibited moderate cytotoxic activity by 50 and 90% mortality rates as LC50 and LC90 values of 5.87 and 9.33 μg/ml respectively. A moderate dose-dependent antidiarrhoeal activity
was found by the methanol extract of the plant.
Key words: Antidiarrhoeal, antimicrobial, cytotoxic, Fimbristylis aphylla
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