Evaluation of antihyperglycemic and antihyperlipidemic activities of Acacia catechu (l.f) willd leaf extract in Wistar albino rats

Abstract

Aim: The aim of the present study was to evaluate the antihyperglycemic and antihyperlipidemic activities of hydroethanolic extract of Acacia catechu (L.f) Willd leaf in streptozotocin (STZ)-induced diabetic rats. Materials and Methods: Diabetic rats were treated with oral administration of hydroethanolic leaf extract of A. catechu (L.f) Willd (200 mg/kg and 400 mg/kg) for 30 days. Various biochemical parameters such as serum glucose, protein, urea, creatinine, lipid profile, and activities of liver and kidney marker enzymes were measured to assess the antihyperglycemic and antihyperlipidemic activities of the extract. Results and Discussion: Administration of the hydroethanolic leaf extract of A. catechu (L.f) Willd (200 mg/kg and 400 mg/kg) significantly decreased (P < 0.05; P < 0.01) blood glucose levels in diabetic rats and has the capacity to correct the metabolic disturbances associated with diabetes. Further, the extract decreased total cholesterol, triglycerides, low-density lipoprotein (LDL), very LDL (VLDL) levels, and increased high-density lipoprotein levels. Conclusion: The present investigation suggested that the administration of A. catechu (L.f) Willd exhibited antidiabetic activity in STZ‑induced diabetic rats and could be considered for further evaluation in drug development.