Pharmacological models to appraisement of antianxiety activity in experimental animals

Abstract

The disease related to brain is very challenging task in the area of neuroscience research. Anxiety is one of the central nervous system disorders in which human feel excessive and unusual fear. Several antianxiety medicines available in market to treat and suppress this problem, but there is lack of evaluation methods available for them. The present review contains all the models such as plus maze apparatus, zero maze apparatus, forced swim apparatus, and open field methods, which are available for pharmacological evaluation of antianxiety. Accuracy can be achieved using these models in a comparative way and one has not to depend on any one model. Several modifications are also possible with these models to achieve accurate and precise result. Working principle of models is enlisted in this review to make them better understandable.