Hypoglycemic effect of black tea extract attenuates carbohydrate metabolic enzymes in streptozotocin-induced diabetic rats

Abstract

Aim: To evaluate the beneficial effects of black tea extract (BTE) on key enzymes of carbohydrate metabolism in streptozotocin -induced diabetic rats. Materials and Methods: Diabetes was induced in male albino Wistar rats by intraperitoneal administration of STZ (40 mg/kg b.wt). Results and Discussion: BTE was administered to diabetic rats at a dose of 100 mg/kg b.wt for 30 days significantly decreased the level of glucose, glycated hemoglobin and increased the levels of insulin. In addition, Black tea administration reinstated the altered carbohydrate metabolizing enzymes to near normal levels. These findings suggest that the administration of black tea extract was potentially ameliorated the carbohydrate metabolizing enzymes in addition to its antihyperglycemic effect. Conclusion: The effect produced by black tea extract on various parameters was comparable to that of glibenclamide- an antidiabetic drug used as a reference drug.