A review on phytochemical and pharmacological aspects of Cissus quadrangularis L.
DOI:
https://doi.org/10.22377/ijgp.v6i3.255Abstract
Cissus quadrangularis L. (Vitaceae) is a common perennial climber, which is distributed throughout Bangladesh. Though almost all of its parts are used in traditional systems of medicines seeds, stem, roots and shoots are the most important parts which are used medicinally. The article reveals that wide numbers of phytochemical constituents have been isolated from the plant which possesses activities like anti‑inflammatory, anti‑tumor, gastro‑protective, antioxidant, antimicrobial and various other important medicinalproperties. The stem juice of plant is used in menstrual disorders, epistaxis and leaves is used against bowel infections. For the last few decades or so, extensive research work has been done to prove its biological activities and pharmacology of its extracts. The current review deals with the enormous amount of updated information of scientific research and reports available in different aspects of this plant involving phytochemical and pharmacology. This review also includes reports on taxonomy, morphology, monographs,
distribution, tissue culture and traditional medicinal uses of the plant.
Key words: Cissus quadrangularis, phytochemical constituents, pharmacological activity, traditional uses
Downloads
References
Newman DJ, Cragg GM. Natural products as sources of new drugs
over the last 25 years. J Nat Prod 2007;70:461‑77.
Hashim H, Kamali EL, Mohammed Y. Antibacterial activity
and phytochemical screening of ethanolic extracts obtained
from selected Sudanese medicinal plants. Curr Res J Biol Sci
;2:143‑6.
Tijani YM, Uguru O, Salawu OA. Anti‑pyretic, anti‑inflammatory
and anti‑diarrhoeal properties of Faidherbia albida in rats. Afr J
Biotechnol 2008;7:696‑700.
Pande PC, Tiwari L, Pande HC. Ethnoveterinary plants of
Uttaranchal‑A review. Indian J Trad Knowl 2007;6:444‑58.
Udupa KN, Chaturvedi GN, Tripathi SN. Advances in research in
Indian medicine. vol. 12. India: Varnasi, Banaras Hindu University;
p. 165‑96.
Enechi OC, Odonwodo I. An assessment of the phytochemical
and nutrient composition of the pulverized root of Cissus
quadrangularis. J Biomed Res 2003;1:63‑8.
Pluenjai T, Saifah E. Constituents of Cissus quadrangularis Linn.
Thai J Pharm Sci 1986;11:205‑11.
Prajapati ND, Purohit SS, Sharma AK. A Hand Book of Medicinal
Plants. India: Agrobios Publication; 2003. p. 145.
Mallika J, Shyamala Devi CS. In vitro and in vivo evaluation of free
radical scavenging potential of Cissus quadrangularis. Afr J Biomed
Res 2005;8:95‑9.
Johns T, Mahunnah RLA, Sanaya P, Chapman L, Ticktin T. Saponins
and phenolic content in plant dietary additives of a traditional
subsistence community, the Batemi of Ngorongoro District,
Tanzania. J Ethnopharmacol 1999;66:1‑10.
Saburi A, Adesanya R, Marie TN, Najeh M, Alain BM, Mary P.
Stilbene derivatives from Cissus quadrangularis. J Nat Prod
;62:1694‑5.
Ambasta SP. The useful plants of India. India: CSIR Publication;
p. 127.
Chopra RN, Nayar SN, Chopra IC. Glossary of Indian Medicinal
Plants. India: CSIR Publication; 1999. p. 66‑7.
Khan SS, Singh MP, Chaghtai SA. Ethnomedicobotany of Cissus
quadrangularis L. Ori J Chem 1991;7:170‑2.
Kumbhojkar MS, Kulkarni DK, Upadhye AS. Ethnobotany of Cissus
quadrangularis L. from India. Ethnobot 1991;3:21‑5.
Austin A, Kannan R, Jagadeesan M. Pharmacognostical studies on
Cissus quadrangularis L. variant I and II. Anc Sci Life 2004;23:33‑47.
Gupta MM, Verma RK. Lipid constituents of Cissus quadrangularis.
Phytochem 1991;30:875‑8.
Rastogi RP, Mehrota BN. Compendium of Indian Medicinal Plants.
India: CSIR; 1993. p. 173‑4.
Anonymous. Indian Medicinal Plants. India: Orient Longman Ltd;
p. 112.
Guhabakshi DN, Pal DC, Sersuma P. A Lexicon of Medicinal Plants
in India. India: Naya Prokash; 2001. p. 443‑5.
Anonymous. Medicinal plants of India. Indian Coun Med Res
;1:242‑5.
Asolkar LV, Kakkar KK, Chakre OJ. Glossary of Indian Medicinal
Plants with Active Principles. vol. 1. (Suppl 2). India: CSIR; 1992.
p. 206.
Kirtikar KR, Basu BD. Indian Medicinal Plants. 2nd ed. USA:
International Book Distributors; 1996. p. 604‑6.
Burkill HM. The useful plants of West Tropical Africa. NHBS, UK:
Royal Botanical Gardens; 2000.
Luseba D, Van der Merwe D. Ethnoveterinary medicine practices
among Tsonga speaking people of South Africa. Onderst J Vet Res
;73:115‑22.
Aswar UM, Bhaskaran S, Mohan V, Bodhankar SL. Estrogenic
activity of friedelin rich fraction (IND‑HE) separated from Cissus
quadrangularis and its effect on female sexual function. Pharmacogn
Res 2010;2:138‑45.
Panthong A, Supraditaporn W, Kanjanapothi D, Taesotikul T,
Reutrakul V. Analgesic, anti‑inflammatory and venotonic effects
of Cissus quadrangularis Linn. J Ethnopharmacol 2007;110:264‑70.
Hatazawa R, Tanigami M, Izumi N, Kamei K, Tanaka A, Takeuchi K.
Prostaglandin E2 stimulates VEGF expression in primary rat
gastric fibroblasts through EP4 receptors. Inflammopharmacology
;15:214‑7.
Singh A, Malhotra S, Subban R. Lichens‑role in traditional medicine
and drug discovery. Int J Integ Biol 2008;3:58.
Potu BK, Rao MS, Nampurath GK, Chamallamudi MR, Prasad K,
Nayak SR, et al. Evidence‑based assessment of antiosteoporotic
activity of petroleum‑ether extract of Cissus quadrangularis
Linn. on ovariectomy‑induced osteoporosis. Ups J Med Sci
;114:140‑8.
Kumar M, Rawat P, Dixit P, Mishra D, Gautam AK, Pandey R,
et al. Anti‑osteoporotic constituents from Indian medicinal plants.
Phytomed 2010;17:993‑9.
Shirwaikar A, Khan S, Malini S. Antiosteoporotic effect of ethanol
extract of Cissus quadrangularis Linn. on ovariectomized rat.
J Ethnopharmacol 2003;89:245‑50.
Potu BK, Nampurath GK, Rao MS, Bhat KM. Effect of Cissus
quadrangularis Linn on the development of osteopenia induced
by ovariectomy in rats. Clin Ter 2011;162:307‑12.
Nalini G, Vinoth PV, Chidambaranathan N, Jeyasundari K.
Evaluation of Anti‑tumour activity of Cissus quadrangularis L.
against Dalton’s ascitic lymphoma and Erlich ascetic induced
carcinoma in mice. Int J Pharm Sci Rev Res 2011;8:75‑9.
Prema R, Sekar DS, Sekhar KB, Jeevanandham S. In vitro cytotoxicity
study on combined plants extracts (Cissus quadrangularis and Aegle
marmelos). Euro J Exp Bio 2012;2:882‑8.
Vijay P, Vijayvergia R. Analgesic, anti‑inflammatory and
antipyretic activity of Cissus quadrangularis. J Pharm Sci Technol
;2:111‑8.
Hasani‑Ranjbar S, Nayebi N, Larijani B, Abdollahi M. A systematic
review of the efficacy and safety of herbal medicines used in the
treatment of obesity. World J Gastroenterol 2009;15:3073‑85.
Oben JE, Ngondi JL, Momo CN, Agbor GA, Sobgui CS. The use
of a Cissus quadrangularis/Irvingia gabonensis combination in the
management of weight loss: A double‑blind placebo‑controlled
study. Lipids Health Dis 2008;7:12.
Greenway FL, Bray GA. Combination drugs for treating obesity.
Curr Diabet Rep 2010;10:108‑15.
Oben J, Kuate D, Agbor G, Momo C, Talla X. The use of a Cissus
quadrangularis formulation in the management of weight loss and
metabolic syndrome. Lipids Health Dis 2006;5:24.
Chidambaram J, Carani Venkatraman A. Cissus quadrangularis stem
alleviates insulin resistance, oxidative injury and fatty liver disease in
rats fed high fat plus fructose diet. Food Chem Toxicol 2010;48:2021‑9.
Jainu M, Vijai MK, Devi CS. Gastroprotective effect of Cissus
quadrangularis extract in rats with experimentally induced ulcer.
Indian J Med Res 2006;123:799‑806.
Soldato ML, Wallace PD. Divergent effects of new cyclooxygenase
inhibitors on gastric ulcer healing: Shifting the angiogenic balance.
Proc Nat Acad Sci 2002;99:13243‑7.
Viswanatha SA, Kulkarni RV, Thippeswamy AH, Koti BC, Gore A.
Evaluation of hepatoprotective activity of Cissus quadrangularis
stem extract against isoniazid‑induced liver damage in rats. Indian
J Pharmacol 2010;42:397‑400.
Jainu M, Vijaimohan K, Kannan K. Cissus quadrangularis L.
Extract attenuates chronic ulcer by possible involvement of
polyamines and proliferating cell nuclear antigen. Pharmacogn
Mag 2010;6:225‑33.
Sanchez‑Fidalgo S, Martin‑Lacave I, Illanes M, Motilva V.
Angiogenesis, cell proliferation and apoptosis in gastric ulcer
healing. Effect of a selective COX‑2 inhibitor. Eur J Pharm
;505:187‑94.
Spiegelman BM, Flier JS. Obesity and the regulation of energy
balance. Cell 2001;104:531‑43.
Jainu M, Devi CS. Invitro and In vivo evaluation of free radical
scavenging potential of Cissus quadrangularis. Afr J Biomed Res
;8:95‑9.
Sanyal A, Ahmad A, Sastry M. Calcite growth in Cissus
quadrangularis plant extract. Curr Sci 2005;89:1742‑5.
Luseba D, Elgorashi EE, Ntloedibe DT, Staden JV. Antibacterial,
anti‑inflammatory and mutagenic effects of some medicinal plants
used in South Africa for the treatment of wounds and retained
placenta in livestock. South Afr J Bot 2007;73:378‑83.
Parekh J. Chanda, SV. Antibacterial activity of aqueous and
alcoholic extracts of Indian medicinal plants against some
Staphylococcus species. Turk J Biol 2008;32:63‑71.
Anitha JR, Akila S, Velliyur KG, Sudarsanam D. Antimicrobial
profile of Cissus quadrangularis. J Herbal Med Toxicol 2010;4:177‑80.
Merinal S, Viji SB. In vitro screening of antimicrobial potentials of
Cissus quadrangularis L. Asian J Plant Sci Res 2012;2:58‑2.
Sen MK, Faruquee HM, Mamun‑or‑Rashid ANM. Antibacterial
Activity of Cissus quadrangularis Stem‑ A Preliminary In vitro Effort
to Develop Antibiotic. Saarbrucken (Germany): Lap‑Lambert
Academic Publishing; 2012. p. 24‑7.
Rajpal V. Standardization of Botanicals. USA: Eastern Publishers;
p. 77‑1.
Paulsen BS, Sekou B, Drissa D, Anna JK, Adsersen A. Antiplasmodial
and GABA benzodiazepine receptor binding activities of
five plants used in traditional medicine in Mali, West Africa.
J Ethnophramacol 2007;110:451‑7.
Balasubramaniana P, Jayalakshmib K, Vidhyab V, Prasada R,
Khaleefathullah SA, Kathiravana G, et al. Antiviral activity of
ancient system of ayurvedic medicinal plant Cissus quadrangularis
L. J Basic Clin Pharm 2010;1:37‑40.
Adzu S, Amos S, Dzarma CW, Gamaniel K. Effect of Zizypus
spinchristi wild aqueous extract on the central nervous system in
mice. J Ethnopharmacol 2002;79:13‑6.
Bum EN, Ngoupaye GT, Talla E, Dimo T, Nkantchoua GC,
Pelanken MM, et al. The anticonvulsant and sedative properties
of stems of Cissus quadrangularis in mice. Afr J Pharm Pharmacol
;2:42‑7.
Attawish A, Chavalttumrong D, Chivapat S, Chuthaputi S,
Rattarajarasroj S, Punyamong S. Subchronic toxicity of Cissus
quadrangularis Linn. Songklanakarin. J Sci Technol 2002;24:
‑51.
Prasad GC, Udupa KN. Effect of Cissus quadrangularis on the
healing of cortisone treated fracture. Indian J Med Res 1963;51:667.
Inngjerdingen K, Nergard CS, Diallo D, Mounkoro PP. An
ethnopharmacological survey of plants used for wound healing in
Dogonland, Mali, West Africa. J Ethnophramacol 2004;92:233‑44.
Sharma N, Nathawat RS, Gour K, Patni V. Establishment of
callus tissue and effect of growth regulators on enhanced sterol
production in Cissus quadrangularis L. Int J Pharmacol 2011;7:653‑8.
Garg P, Malik CP. Multiple shoot formation and efficient root
induction in Cissus quadrangularis. Int J Pharm Clin Res 2012;4:4‑10.