Protective action of hydroethanolic extract of Moringa oleifera flower on acetaminophen-induced hepatotoxicity in rats

Abstract

Background/Aims: The present study was to investigate the possible hepatoprotective action of the hydroethanolic extract of Moringa oleifera (MO) flowers in comparison to hepamerz (positive control) against long-term hepatotoxicity induced by acetaminophen (APAP) in albino Wistar rat (male). Methods: In this study, different groups of animals were treated with APAP (300 mg/kg body weight), both APAP (300 mg/kg body weight) and MO flower hydroethanolic extract (400 mg/kg body weight), both APAP (300mg/kg body weight) and hepamerz (150 mg/kg body weight), respectively. Results: Liver function tests were analyzed, and histopathological changes of liver were also observed along with antioxidant enzymes and lipid peroxidation. APAP-induced hepatotoxicity increases the serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), alkaline phosphatase (ALP), and decreases the level of total serum protein, where significant decrease in SGOT, SGPT, and ALP and significant increase in total serum protein were observed in the MO flower hydroethanolic extract-treated animals. Oxidative stress was also observed in APAP treated group and reduction in stress was also noted after hepamerz and MO supplementation. Conclusion: It can be concluded that hydroethanolic extract of MO flower has potency as a hepatoprotective agent like hepamerz against APAP-induced hepatotoxicity on albino rats.