Caraway distillate ameliorate hyperlipidemia and hepatic steatosis in obese rat

Abstract

Background: Carum carvi L. (family; Apiaceae, common name; caraway) is conventionally used for the treatment of flatulence, dyspepsia, fatness, asthma, and amenorrhea in Unani as well as the Ayurvedic System of Indian Medicine. Aim and Objective: The present study was planned to scrutinize the effect of caraway distillate (CD) on hyperlipidemia and hepatic steatosis in a rat model of high-fat diet (HFD)-induced obesity. Materials and Methods: HFD-fed rats were administered with CD (7.75 ml/kg body weight [BW] twice a day, orally) and CD1 (7.75 ml/kg BW once a day, orally) for 4 weeks. Results: After termination of the study, CD and CD1 treatments showed significant (P < 0.001) attenuation in cholesterol, triglycerides, low-density lipoprotein cholesterol, leptin levels, and pancreatic lipase activity and significant (P < 0.001) boost in highdensity lipoprotein cholesterol. Furthermore, CD and CD1 treatment also noticeably attenuated the extent of hepatic steatosis. Conclusions: These results suggest that CD has a strong protective effect against hyperlipidemia and hepatic steatosis in HFD-induced obesity on a rat model.