Phytochemistry and Ethno Biological discussion of Ajos sacha

Abstract

Introduction: Plants have been utilized as a source of medicine for a long time. Scientists have successfully mended several abnormal health disorders by boosting traditional pharmaceuticals since the beginning of time. This implies concentrating on a wide range of biological activities to illuminate potential secondary metabolite modes of action. Materials and Methods: The study was carried out using literature review using keywords such as Ajos sacha, Adenocalymma alliaceum Miers through search engine Google Scholar, Science direct, PubMed, and Elsevier. Result and Discussion: The Ajos Sacha has many active metabolites and sulfur compounds similar to garlic. Furthermore, due to biologically abundant active secondary metabolites such as polyphenol, flavonoid, tannic acid, and sulfur compounds, the plant has been documented for numerous biological activities such as antibacterial activity, anti-inflammatory activity, antifungal activity, anticancer activity, anthelmintic activity, larvicidal activity, and hypocholesterolemic activity. Due to the presence of sulfur in garlic creeper, the plant has shown inhibition of tubulin polymerization or impedes the G2-M phase via Cdc25C signaling. In addition, the Ajos Sacha flower extract inhibits phosphatidylserine translocation, and caspase-3 activation causes apoptosis. The Ajos Sacha was also documented due to its inhibition characteristic on tubulin polymerization or blocking the G2-M phase via Cdc25C signaling. Conclusion: This review presents the role of Ajos Sacha on biological activities, including free radical scavenging property. Henceforth, this plant can be utilized in clinical screening too.