Anti‑allergic and anti‑anaphylactic activities of Dolichos biflorus
DOI:
https://doi.org/10.22377/ijgp.v7i3.322Abstract
Background: The seeds of Dolichos biflorus (DB) have been traditionally used in the treatment of cough and asthma. Aim: Based on the traditional claim, the present study was planned to evaluate the anti‑allergic and anti‑anaphylactic activities of DB.Materials and Methods: The ethanolic extract of the seeds of DB was prepared by cold maceration process. DB was subjected
to phytochemical screening, acute toxicity studies, mast cell‑stabilizing activity using compound 48/80 and anti‑allergic activity using milk‑induced leukocytosis and eosinophilia and passive paw anaphylaxis. Statistical Analysis: Statistical analysis was done by using one‑way analysis of variance followed by Dunnett’s test. Results: The phytochemical investigation showed presence of proteins, flavonoids and glycosides. DB extract inhibited milk‑induced leukocytosis and eosinophilia and also the compound 48/80 induced mast cell degranulation. DB extract significantly reduced passive paw anaphylaxis in a dose‑dependent manner.
Conclusion: The results demonstrated that DB extract possesses anti‑allergic and anti‑anaphylactic potentials that might be useful
in the management of asthma.
Key words: Compound 48/80, Dolichos biflorus, milk, passive paw anaphylaxis
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