Development and characterization of oral fast-dissolving strip incorporated with olmesartan medoxomil nanocrystals for solubility enhancement: Multilevel categoric optimization using DOE

Authors

  • R. Nithya

DOI:

https://doi.org/10.22377/ijgp.v16i02.3222

Abstract

Aim: Olmesartan medoxomil (OLM) is an antihypertensive drug available as an oral solid dosage form (tablet)
with a restricted bioavailability of 28.6%. This might be attributed due to the low solubility and low permeability
of the drug. The primary goal of this study was to enhance the solubility of OLM by formulating OLM nanocrystals
(NC) and incorporating them into Oral Fast-Dissolving Strips (OFDSs) that will be made available for geriatric
patients.

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Published

2022-06-15

Issue

Vol. 16 No. 02 (2022): International Journal of Green Pharmacy

Section

Original Article