Evaluation of antidepressant effect of Drakshasava in Wistar rats

Abstract

Introduction: Depression is a common clinical condition observed in all the age group. Presently available drugs
are having many adverse effects. Literature suggests Drakshasava can be used in patients suffering from anxiety
and depressive disorders. Aims: The aim of the study was to evaluate antidepressant activity of Drakshasava in
experimental models. Materials and Methods: The antidepressant activity was studied in albino Wistar rats using
models for locomotor activity with actophotometer, forced swimming test (FST), sucrose preference test (SPT),
and measuring the cortisol levels. Fluoxetine (30 mg/kg) was used as standard drugs and two doses of Drakshasav
were used (2 ml, 4 ml/kg). Results: Drakshasav produced significant decrease in duration of immobility in FST
and increase in locomotor activity and sucrose drinking. Furthermore, significant decrease in the cortisol levels
was observed. Conclusion: Drakshasav showed promising antidepressant activity in FST and SPT. It can be used
as an adjuvant in the treatment of depression.