Pharmacological and therapeutic review of ashtamangal ghrita – An amazing ayurvedic formulation for CNS

Abstract

Cognitive dysfunction and neurological disorders are major concerns in pediatrics. Ayurveda has a deep acumen
for the prophylactic and curative management of neurological disorders in the developing brain. This study is
done to review the neuroprotective and nootropic activity of an Ayurvedic drug Ashtamangal Ghrita (AMG).
Various experimental and clinical studies on AMG and its contents demonstrate their efficacy against several
Central Nervous System (CNS) ailments such as cerebral palsy, seizure disorders, autism, and attention deficit
hyperactivity disorder by their neuroprotective, nerve regenerative, nootropic, anticonvulsant, antioxidant, and
adaptogenic properties. The drug AMG is in the Ghrita form, thereby advantage of its lipid solubility, is it can
pass through the Blood-brain barrier thus corroborating it as an excellent drug for CNS. Toxicological studies also
substantiate the safety of the drug for therapeutic usage. The constituents of AMG also own CNS protective and
nootropic properties, thereby helping in improving intellect and memory in children. Hence, AMG can prove to
be a promising neuroprotective and intellect-promoting drug for cognitive dysfunction and various neurological
disorders in children. The present review aims to analytically evaluate and systematically summarize experimental
and clinical trial outcomes and the safety profile of AMG.