Sweet flag (Acorus calamus Linn.): An incredible medicinal herb
DOI:
https://doi.org/10.22377/ijgp.v7i4.336Abstract
The aim of the present paper is to provide information regarding the ethnopharmocology, ethnobotany, therapeutic uses and scientific studies carried out on sweet flag (Acorus calamus Linn). The search was carried out by examining the classical texts of Unani, Ayurveda and other traditional medical systems, as well as the ethnobotanical literature and Google scholar. The drug is popularly known as “Sweet flag†in traditional medicine and used to treat a number of diseases. The plant has a rich ethnobotanical history dating possibly back to the time of Moses in the Old Testament of the Bible and in early Greek and Roman medicine. Sweet flag has been valued for its rhizome and fragrant oils which have been used medicinally, in alcoholic beverages, as a fragrant essence in perfumes and oils, andfor insecticidal properties. Chemical analysis of sweet flag shows that it contains sesquiterpenes, flavonoids, α‑ and β‑asarone and
various other constituents. Research studies have shown that it possesses various pharmacological activities. An extensive review of the ancient traditional literature and modern research revealed that the drug has numerous therapeutic actions, several of which have been established scientifically which may help the researchers to set their minds for approaching the utility, efficacy and potency of sweet flag.
Key words: Ethnobotany, sweet flag, traditional medicine, Unani medicine, β‑asarone
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References
Balakumbahan R, Rajamani K, Kumanan K. Acorus calamus: An
overview. J Med Plant Res 2010;4:2740‑45.
Paithankar VV, Belsare SL, Charde RM, Vyas JV. Acorus calamus:
An overview. Int J Biomed Sc. 2011;2:518‑29.
Singh R, Sharma PK, Malviya R. Pharmacological Properties and
Ayurvedic value of Indian Buch Plant. (Acorus calamus): A short
review. Advan Biol Res 2011;5:145‑54.
Kirtikar KR, Basu BD. Indian medicinal plants., Vol. 4, 2nd ed.
Dehradun: International Book Distributors; 2007. p. 2628‑9.
Divya G, Gajalakshmi S, Mythili S, Sathiavelu A. Pharmacological
Activities of Acorus calamus: A review. Asian J Biochem Pharm Res
;1:57‑64.
Anonymous. The wealth of India, Vol. 1. New Delhi: Council of
Scientific and Industrial Research; 2004. p. 19‑65.
Raja AE, Vijayalakshmi M, Devalarao G. Acorus calamus linn:
Chemistry and Biology. Res J Pharm Tech 2009;2:256‑61.
Dong W, Yang D, Runhua Lu. Chemical Constituents from the
Rhizome of Acorus calamus L. Planta Med 2010;76:454‑7.
Motley TJ. The ethnobotany of sweet flag, Acorus calamus (Araceae).
Economic Botany 1994;48:397‑412.
Mukhia PK. Management guide for Acorus calamus and
Neopicrorhiza. Thimphu: Royal Government of Bhutan Ministry
of Agriculture Dept. of Forest Resources Development Division.
Thimphu: FRDD; 2004. p. 1‑23.
Lokesh GB. Sweet flag (Acorus calamus): Cultivation and economics
aspects. Nat Prod Rad 2004;3:19‑21.
Available from: http://www.herbalcureindia.com/herbs/
acorus‑calamus.htm [Last accessed on 2012 Nov 29].
Nadkarni KM. Indian Plants and Drugs with their medicinal
properties and Uses. New Delhi: Srishti Book Distributors; 2005.
p. 16‑7.
Dwivedi P, Singh R, Malik MT, Jawaid T. A traditional approach
to herbal Nootropic agents: An overview. Int J Pharm Sci Res
;3:630‑6.
Prisilla DH, Balamurugan R, Shah HR. Antidiabetic activity of
methanol extract of Acorus calamus in STZ induced diabetic rats.
Asian Pac J Trop Biomed 2012;2 Suppl 2:941‑6.
Gopalakrishna HN, Sudhakar P, Shilin G, Shenoy AK, Holla, GK,
Nair V, et al. Effect of Acorus calamus on electrical and chemical
induced seizures in mice. Int J Appl Biolo Pharma Technol
;1:465‑72.
Tripathi AK, Singh RH. Clinical study on an indigenous drug
vaca (Acorus calamus) in the treatment of depressive illness. J Res
Ayur Siddha 1995;16:24‑34.
Vengadesh PK, George T, Vinoth KR, Nancy J, Kalaivani M,
Vijayapandi P. Neuromodulatory effect of Acrous calamus leaves
extract on dopaminergic system in mice. Int J Pharm Tech Res
;1:1255‑9.
Gaidhani SN, Lavekar GS, Juvekar AS, Sen S, Singh A, Kumari S.
In‑vitro anticancer activity of standard extracts used in ayurveda.
Phcog Mag 2009;5:425‑9.
Subathraa K, Poonguzhali TV. In vitro studies on antioxidant and
free radical scavenging activities of aqueous extract of Acorus
calamus L. Int J Curr Sci 2012;1:69‑73.
Patel P, Vaghasiya J, Thakor A, Jariwala J. Antihypertensive effect
of rhizome part of Acorus calamus on renal artery occlusion induced
hypertension in rats. Asian Pac J Trop Dis 2012;2 Suppl 1:6‑10.
Silprasit K, Seetaha S, Pongsanarakul P, Hannongbua S,
Choowongkomon K. Anti‑HIV‑1 reverse transcriptase activities
of hexane extracts from some Asian medicinal plants. J Med Plant
Res 2011;5:4194‑201.
Rajkumar V, Guha G, Kumar RA, Mathew L. Evaluation of
cytotoxic potential of Acorus calamus rhizome. Ethnobotanical
Leaflets 2009;7:832‑9.
Mehrotra S, Mishra KP, Maurya R, Srimal RC, Yadav VS,
Pandey R, et al. Anticellular immunosuppressive properties of
ethanolic extract of Acorus calamus rhizome. Int Immunopharmacol
;3:53‑61.
Sandeep D, Nair CK. Radioprotection by Acorus calamus: Studies
on in vivo DNA damage and repair. Int J Low Radiat 2010;7:121‑32.
Shah AJ, Gilani AH. Aqueous‑methanolic extract of sweet
flag (Acorus calamus) possesses cardiac depressant and
endothelial‑derived hyperpolarizing factor‑mediated coronary
vasodilator effects. J Nat Med 2012;66:119‑26.
Gilani AH, Shah AJ, Ahmad M, Shaheen, F. Antispasmodic effect
of acorus calamus Linn. Is mediated through calcium channel
blockade. Phytother Res 2006;20:1080‑4.
Wu HS, Zhu DF, Zhou CX, Feng CR, Lou YJ, Yang B, et al. Insulin
sensitizing activity of ethyl acetate fraction of Acorus calamus L. in
vitro and in vivo. J Ethnopharmacol 2009;123:288‑92.
Jain N, Jain R, Jain A, Jain DK, Chandel HS. Evaluation of
wound‑healing activity of acorus calamus Linn. Nat Prod Res
;24:534‑41.
Kim H, Han TH, Lee SG. Anti‑inflammatory activity of a water
extract of Acorus calamus L. leaves on keratinocyte HaCaT cells.
J Ethnopharmacol 2009;122:149‑56.
Merekar AN, Pattan SR, Parjane SK, Nirmal SA, Patel DS,
Shitre MR, et al. Synergistic Anthelmintic activity of rhizomes of
Acorus calamus and roots of Vitex negundo. Pharmacologyonline
;3:209‑12.
Palani S, Raja S, Kumar RP, Venkadesan D, Devi K, Sivaraj A, et al.
Therapeutic efficacy of antihepatotoxic and antioxidant activities
of Acorus calamus on acetaminophen‑ induced toxicity in Rat. Int
J Integ Biol 2009;7:39‑44.
Mamgain P, Singh RH. Control clinical trial of the lekhaniya drug
vaca (Acorus calamus) in case of ischemic heart diseases. J Res Ayur
Siddha 1994;15:35‑51.
Begum J, Yusuf M, Chowdhury JU, Khan S, Anwar MN. Antifungal
activity of forty higher plants against phytopathogenic Fungi.
Bangladesh J Microbiol 2007;24:76‑8.
Manikandan S, Devi RS, Srikumar R, Thangaraj R, Ayyappan R,
Jegadeesh R, et al. In‑vitro antibacterial activity of aqueous and
ethanolic extracts of Acorus calamus. Int J Appl Biol Pharm Technol
;1:1072‑5.
Hosen SM, Das R, Rahim ZB, Chowdhury N, Paul L, Saha D, et al.
Study of analgesic activity of the methanolic extract of Acorus
calamus L. and Oroxylum indicum vent by Acetic acid induced
writhing method. Bull Pharm Res 2011;1:63‑7.
Nethengwe MF, Opoku AR, Dludla PV, Madida KT, Shonhai A,
Smith P, et al. Larvicidal, antipyretic and antiplasmodial
activity of some Zulu medicinal plants. J Med Plant Res 2012;6:
‑62.
Shah AJ, Gilani AH. Bronchodilatory effect of Acorus calamus (Linn.)
is mediated through multiple pathways. J Ethnopharmacol
;131:471‑7.
Nalamwar VP, Khadabadi SS, Aswar PB, Kosalge SB, Rajurkar RM,
et al. In vitro Licicidal Activity of Different Extracts of Acorus calamus
Linn. (Araceae) Rhizome. Int J Pharm Tech Res 2009;1:96‑100.
Imam H, Zarnigar, Sofi G. Mosquito Larvicidal efficacy of Acorus
calamus extracts against Aedes aegypti L. larvae. Asian Pac J Trop
Biomed 2012;2:1‑4.
Rehman J, Jilani G, Khan MA, Masih R, Kanvil S. Repellent and
Oviposition Deterrent Effects of Indigenous Plant Extracts to
Peach Fruit Fly, Bactrocera zonata Saunders (Diptera: Tephritidae).
Pakistan J Zool 2009;41:101‑8.
Muthuraman A, Singh N. Acute and sub‑acute oral toxicity profile
of Acorus calamus (Sweet flag) in rodents. Asian Pac J Trop Biomed
;2 Suppl 2:1017‑23.
