Clinical and metabolic markers based study of Swas Kasa Chintamani Rasa (An Ayurvedic herbo‑metallic preparation) in childhood bronchial asthma (Tamak Swas)
DOI:
https://doi.org/10.22377/ijgp.v8i1.351Abstract
Background: Asthma is a problem worldwide, with an estimated 300 million affected individuals. It is a disease of the respiratorysystem, characterised by intermittent inflammation, constriction or obstruction of the airways leading to a temporary reduction in
airflow, and associated shortness of breath. Aims: In Ayurveda, there are lots of drugs to treat the bronchial asthma (Tamak Swas), among them Swas‑Kasa‑Chintamani Rasa (SKCR) is considered a good drug to cure. Materials and Methods: A total of consented 23 children of both sex under 12 years of age were included in the study and divided into three groups, blood samples were collected before treatment and after the completion of therapy for the metabolic markers like Hb gm%, TLC, AEC, S. Protein, S. Albumin, SGOT, SGPT, alkaline phosphatase and S. Bilirubin. SKCR was given for a total of 45 days in a dose of 4 mg/kg/dose × 12 hourly with
garlic, ginger and honey in ratio of 1:2:4. Statistical Analysis Used: In the present study, SPSS software was used to get statistical data such as Mean (X–), Mean Difference (Ä), Standard Deviation (SD) and Student’s “t†test, etc. Results and Conclusions: The findings suggest that the drug is more effective in those cases who are not receiving corticosteroid with bronchodilator in comparison to children receiving corticosteroids with/without bronchodilator. No specific adverse effect of drug SKCR was observed.
Key words: Ayurved, childhood bronchial asthma, SGOT, SGPT, Swas Kasa Chintamani Rasa
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References
Masoli M, Fabian D, Holt S, Beasley R. The global burden
of asthma: Executive summary of the GINA Dissemination
Committee report. Allergy 2004;59:469‑78.
Bray MA, Kehle TJ, Grigerick SE, Loftus S, Nicholson H. Children
with asthma: Assessment and treatment in school settings.
Psychology in the Schools. Vol. 45. Hoboken: Wiley Periodicals,
Inc; 2008.
American Lung Association. (2006a, August). Childhood
asthma overview. Available from: http://www.lungusa.org/site/
pp.asp [Last accessed on 2007 Sept 17].
Global Strategy for Asthma Management and Prevention;2007.
Lau S, Illi S, Sommerfeld C, Niggemann B, Bergmann R, von
Mutius E, Wahn U. Early exposure to house‑dust mite and cat
allergens and development of childhood asthma: A cohort study.
Multicentre Allergy Study Group. Lancet 2000;356:1392‑7.
Illi S, von Mutius E, Lau S, Nickel R, Gruber C, Niggemann B,
et al. Multicentre Allergy Study Group. The natural course of
atopic dermatitis from birth to age 7 years and the association
with asthma. J Allergy Clin Immunol 2004;113:925‑31.
Castro‑Rodriguez JA, Holberg CJ, Wright AL, Martinez FD.
A clinical index to define risk of asthma in young children with
recurrent wheezing. Am J Respir Crit Care Med 2000;162:1403‑6.
Guilbert TW, Morgan WJ, Zeiger RS, Mauger DT, Boehmer SJ,
Szefler SJ, et al. Long‑term inhaled corticosteroids in preschool
children at high risk for asthma. N Engl J Med 2004;354:1985‑97.
Johnston SL, Pattemore PK, Sanderson G, Smith S, Lampe F,
Josephs L, et al. Community study of role of viral infections in
exacerbations of asthma in 9‑11 year old children. BMJ 1995;310:1225‑9.
Heymann PW, Carper HT, Murphy DD, Platts‑Mills TA, Patrie J,
McLaughlin AP, et al. Viral infections in relation to age, atopy, and
season of admission among children hospitalized for wheezing.
J Allergy Clin Immunol 2004;114:239‑47.
Sigurs N. Clinical perspectives on the association between
respiratory syncytial virus and reactive airway disease. Respir
Res 2002;3 Suppl 1: 8‑S14.
Illi S, von Mutius E, Lau S, Bergmann R, Niggemann B,
Sommerfeld C, et al., MAS Group. Early childhood infectious
diseases and the development of asthma up to school age: A birth
cohort study. BMJ 2001;322:390‑5.
Martinez FD, Wright AL, Taussig LM, Holberg CJ, Halonen M,
Morgan WJ. Asthma and wheezing in the first six years of life. The
Group Health Medical Associates. N Engl J Med 1995;332:133‑8.
Gauderman WJ, Avol E, Lurmann F, Kuenzli N, Gilliland F, Peters
J, et al. Childhood asthma and exposure to traffic and nitrogen
dioxide. Epidemiology 2005;16:737‑43.
Millstein J, Gilliland F, Berhane K, Gauderman WJ, McConnell R,
Avol E, et al. Effects of ambient air pollutants on asthma medication
use and wheezing among fourth‑grade school children from 12
Southern California communities enrolled in The Children’s
Health Study. Arch Environ Health 2004;59:505‑14.
Devereux G, Seaton A. Diet as a risk factor for atopy and asthma.
J Allergy Clin Immunol 2005;115:1109‑17. Diagnosis and treatment
of asthma in childhood: A PRACTALL consensus reportA.
Bernard A, Carbonnelle S, Michel O, Higuet S, De Burbure C,
Buchet JP, et al. Lung hyperpermeability and asthma prevalence
in schoolchildren: Unexpected associations with the attendance
at indoor chlorinated swimming pools. Occup Environ Med
;60:385‑94.
Lee TH, Anderson SD. Heterogeneity of mechanisms in exercise
induced asthma. Thorax 1985;40:481‑7.
Parsons JP, Mastronarde JG. Exercise‑induced bronchoconstriction
in athletes. Chest 2005;128:3966‑74.
Villeneuve PJ, Leech J, Bourque D. Frequency of emergency room
visits for childhood asthma in Ottawa, Canada: The role of weather.
Int J Biometeorol 2005;50:48‑56.
Wright RJ, Cohen S, Carey V, Weiss ST, Gold DR. Parental stress
as a predictor of wheezing in infancy: A prospective birth‑cohort
study. Am J Respir Crit Care Med 2002;165:358‑65.
Charak Chikitsa 17/65‑67, Charaka Samhita, ‘Vidyotini’ Hindi
commentary by Shastri PK, Chaturvedi GN. Part‑II, Varanasi:
Chaukhambha Bharati Academy;1998.
Gupta S, Assessment of Effect of ‘Svas‑Kas‑Chintamani Rasa’ in
Bronchial‑Asthmaâ€. M.D. Thesis Deptt. Of Balroga IMS BHU 2006.
Rasa Chandanshu, Hikka Shvasa – Chikitsa. Rasa Chandanshu/
Rasa Ratna Sangraha, Translated by Berakar VD. 3rd ed. Pune: Sree
Gajanan Book Depo; 1983. p. 295, Shlok no. 106‑108.
Rasendra Sar Sangraha 3/19‑21, Rasendra Sara Sangraha of Sri
Gopal Krishna, text with English translation by Satpute AD,
Varanasi: Chowkhamba Krishnadas Academy;2003.
Hariprapannaji VP. Rasa‑Yoga Sagar 2nd Part. Rasayogasagara.
Varanasi: Krishnadas Academy; 1983. p. 466‑1.
Sundaram BR. Shvasadhikar. p. 438
Gopal KK. Rasatantra Sar and Siddha Prayoga Samgarh.
nd Vol. 13/1, Rasatantrasar and Siddha Prayog Sangrah, 2nd Part.
Ajmer: Krishna Gopal Ayurved Bhawan.
Vrihad Vaidhyak Grantha Dhanwantri, published from
Chaukhambha Sanskrit Sansthan, India. p. 230
Bhaishajya Ratnawali, Hikka Shvasa Chikitsa 16/57‑60). Bhaisajya
Ratnavali, ‘Vidyotini’ Hindi commentary by Shastri A. Varanasi:
Chaukhambha Sanskrit Sansthan. India; 2005.
Agency for Toxic Substances and Disease Registry (ATSDR).
Toxicological Profile for Mercury. Atlanta: US Department of
Health and Human Services;1999.
Torres AD, Rai AN, Hardiek ML. Mercury intoxication and arterial
hypertension: Report of two patients and review of the literature.
Pediatrics 2000;105:E34.
Sorensen N, Murata K, Budtz‑Jørgensen E, Weihe P, Grandjean P.
Prenatal methylmercury exposure as a cardiovascular risk factor
at seven years of age. Epidemiology ;10:370‑5.
Grandjean P, Murata K, Budtz‑Jørgensen E, Weihe P. Cardiac
autonomic activity in methylmercury neurotoxicity: 14‑year
follow‑up of a Faroese birth cohort. J Pediatr 2004;144:169‑76.
Li AM, Chan MH, Leung TF, Cheung RC, Lam CW, Fok TF.
Mercury intoxication presenting with tics. Arch Dis Child
;83:174‑5.
Kang‑Yum E, Oransky SH. Chinese patent medicine as a potential
source of mercury poisoning. Vet Hum Toxicol ;34:235‑8.
Afonso J, deAlvarez RR. Effects of mercury on human gestation.
Am J Obstet Gynecol 1960;80:145‑54.
Chugh KS, Singhal PC, Uberoi HS. Rhabdomyolysis and
renal failure in acute mercuric chloride poisoning. Med J Aust
;2:125‑6.
Murphy MJ, Culliford EJ, Parsons V. A case of poisoning with
mercuric chloride. Resuscitation 1979;7:35‑44.
