Immunostimulatory effect of Mimusops elengi Linn stem bark in mice
DOI:
https://doi.org/10.22377/ijgp.v8i3.380Abstract
Objectives: To scrutinise the immunostimulatory activity of methanolic extract of bark of Mimusops elengi Linn (MEMEL) inmice. Materials and Methods: The MEMEL was administered orally at the dose of 10, 20, 40 mg/kg/day body weight in mice. The
immunostimulatory activities on specific and non‑specific immunity were studied by carbon clearance test (CCT), haemagglutination antibody (HA) and delayed type hypersensitivity, using sheep red blood cells (SRBC) as the antigen. Distilled water served as a control in all the tests and vitamin E 150 mg/kg was used as standard. Result: Oral administration of MEMEL showed a dose‑dependent
increased immunostimulatory response. Phagocytic index was found to be increased significantly (P < 0.01) in CCT. The production of circulatory antibody titre (humoral antibody response) was increased significantly (P < 0.01) and delayed type hypersensitivity reaction was found to be augmented less significantly (P < 0.05) by increasing the mean footpad thickness at 48 hr in response to SRBC as an antigen. Conclusion: This finding suggests that the MEMEL possesses potential for augmenting immune activity by cellular and humoral‑mediated mechanisms.
Key words: Antibody titre, delayed type hypersensitivity, immunostimulant, Mimusops elengi Linn, phagocytosis
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References
Baker DD, Chu M, Oza U, Rajgarhia V. The value of natural
products to future pharmaceutical discovery. Nat Prod Rep
;24:1225‑44.
Chin YW, Balunas MJ, Chai HB, Kinghorn AD. Drug discovery
from natural sources. AAPS J 2006;8:E239‑53.
Kadam PV, Deoda RS, Shivatare RS, Yadav KN, Patil MJ.
Pharmacognostic, phytochemical and physiochemical studies of
Mimusops elengi Linn stem bark (Sapotaceae). Der Pharmacia Lettre
;4:607‑13.
Sharma V, Thakur M, Chauhan NS, Dixit VK. Immunomodulatory
activity of petroleum ether extract of Anacyclus pyrethrum. Pharm
Biol 2010;48:1247‑54.
Satpute KL, Jadhav MM, Karodi RS, Katare YS, Patil MJ,
Rub R, et al. Immunomodulatory activity of fruits of Randiadum
etorum Lamk. J Pharmacog Phytother 2009;1:56‑60.
Singh S, Cps Y, Noolvi MN. Immunomodulatory activity of butanol
fraction of Gentiana olivieri Griseb on Balb/C mice. Asian Pac J
Trop Biomed 2012;2:433‑7.
Bakula MR. A reputed drugs of ayurveda, its history‑uses in Indian
medicine. Indian J Hist Sci 1981;16:169‑80.
Nadkarni KM. Indian Materia Medica 2. 3rd ed. Mumbai: Popular
Prakashan; 1996. p. 596‑599.
Sharma PC, Yelne MB, Dennis TJ. Database on Medicinal Plants
Used in Ayurveda. Vol. 1. India: Central council for Research in
Ayurveda and siddha; 2000. p. 65‑72.
Manjeshwar SB, Ramakrishna JP, Harshith PB, Princy LP, Rekha B.
Chemistry and medicinal properties of the Bakul (Mimusops elengi
Linn): A review. Food Res Int 2011;44:1823‑9.
Mishra G, Mitra CR. Constituents of bark of Mimusops Elengi
linn. Phytochemistry 1967;6:1909.
Jahan N, Ahmed W, Malik A. A lupene‑type triterpene from
Mimusops Elengi. Phytochemistry 1995;39:255‑7.
Aher VD, Wahi VA. Pharmacological study of Tinospora Cordifolia
as an immunomodulator. Int J Curr Pharm Res 2010;2:52‑54.
Dashputre NL, Naikwade NS. Immunomodulatory activity
of abutilon indicum linn on albino mice. Int J Pharm Sci Res
;1:178‑84.
Patel S, Banji D, Banji OJ, Patel MM, Shah KK. Scrutinizing the role
of aqueous extract of Trapa bispinosa as an immunomodulator in
experimental animals. Int J Res Pharm Sci 2010;1:13‑9.
Tilwari A, Shukla NP, Pathirissery UD. Immunomodulatory
activity of the aqueous extract of seeds of Abrus precatorius
Linn (Jequirity) in mice. Iran J Immunol 2011;8:96‑103.
Ismail S, Asad M. Immunomodulatory activity of Acacia catechu.
Indian J Physiol Pharmacol 2009;53:25‑33.
Mazumder PM, Pattnayak S, Parvani H, Sasmal D,
Rathinavelusamy P. Evaluation of immunomodulatory activity
of Glycyrhiza glabra L roots in combination with zing. Asian Pac
J Trop Biomed 2012;1:15‑S20.
Kasote DM, Zanwar AA, Devkar ST, Hegde MV, Deshmukh KK.
Immunomodulatory activity of ether insoluble phenolic
components of n‑butanol fraction (EPC‑BF) of flaxseed in rat.
Asian Pac J Trop Biomed 2012;2:623‑S6.
Bafna AR, Mishra SH. Immunomodulatory activity of petroleum
ether extract of flower‑heads of Sphaeranthus indicus Linn.
J Herbal Pharmacother 2007;7:25‑37.
Patil CR, Salunkhe PS, Gaushal MH, Gadekar AR, Agrawal AM,
Surana SJ. Immunomodulatory activity of Toxicodendron
pubescens in experimental models. Homeopathy 2009;98:154‑9.
Bhadoriyalb SS, Mandoriya N. Immunomodulatory effect
of Tricosanthes Dioica Roxb. Asian Pac J Trop Biomed
;2:985‑S7.
Makare N, Bodhankar S, Rangari V. Immunomodulatory activity of
alcoholic extract of Mangifera indica L. in mice. J Ethnopharmacol
;78:133‑7.
Dashputre NL, Naikwade NS. Preliminary immunomodulatory
activity of aqueous and ethanolic leaves extracts of Ocimum
basilicum Linn in Mice. Int J Pharm Tech Res 2010;2:1342‑9.
Atal CK, Sharma ML, Kaul A, Khajuria A. Immunomodulating
agents of plant origin. I: Preliminary screening. J Ethanopharmacol
;18:133‑41.
Mukherjee D, Khatua TN, Venkatesh P, Saha BP, Mukherjee PK.
Immunomodulatory potential of rhizome and seed extracts of
Nelumbo nucifera Gaertn. J Ethanopharmacol 2010;128:490‑4.
