Comparative physicochemical evaluation of a herbo‑mineral unani formulation: Kushta kharmohra
DOI:
https://doi.org/10.22377/ijgp.v8i3.383Abstract
Background: Kushtas are biologically nano‑crystals having size of 1‑100 nm and are respected for their instant therapeutic effect.In classical Unani text various methods are described for the preparation of Kushta kharmohra (cowrie ash). They address different ailments but are considered to be same medicinal substance. Objective: The present study was aimed at comparative physicochemical evaluation of Kushta kharmohra prepared by different processing methods by using classical as well as modern scientific techniques. Material and Methods: After detoxification Kushta kharmohra method 1 was (KKM1) prepared on iron pan while Kushta kharmohra method 2 (KKM2) was prepared in muffle furnace and evaluated for physicochemical characteristics including preliminary tests.
Results: Floating, fineness test were positive for both the kushtas indicated correct preparation. Bulk density (0.80 ± 0.00 and 0.93 ± 0.00 g/ml), tapped density (1.26 ± 0.00 and 1.55 ± 0.00 gm/ml), Hausner ratio (1.57 ± 0.00 and 1.67 ± 0.01), compressibility index (36.24 ± 0.14 and 40.25 ± 0.41%), loss of weight on drying (0.001 ± 0.00 and 0.0005 ± 0.00%), pH of 1% and 10% solution (8.09 ± 0.02, 8.20 ± 0.01 and 11.08 ± 0.02, 11.28 ± 0.01) total ash, acid insoluble ash, water soluble (94.36 ± 0.04, 63.51 ± 0.17, 81.29 ± 0.20 and 94.74 ± 0.07, 92.44 ± 0.06, 10.16 ± 0.01%) and extractive values (0.8 ± 0.03 and 2.4 ± 0.06%) were reported in KKM1 and KKM2, respectively. Conclusion: The modern parameters confirmed that there was difference between both kushtas due to different methods
of preparation. It indicates that proccessing method also imparts its effect on finished product. Different physico‑chemical properties might be the factor responsible for different indications of kushta kharmohra in different ailments.
Key words: Cowrie, Kushta, quality control, Unani
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References
Said HM. Hamdard Pharmacopoiea of Eastern Medicine.
New Delhi: Sri Satguru publication; 1997. p. 222‑23, 231.
Kabeeruddin HM. Kitabul Taklees. New Delhi: Central Council
of Research in Unani Medicine; YNM. p. 185‑8.
Balfur E. The Cyclopaedia of India and of Eastern and Southern
Asia. Vol 3. Madras: Scottish and foster press; 1968. p. 648.
Mhatre PR, Desa i G , P r i n c i p l e s of I n t e g r a t e d
Medicine: Stepping Beyond Alternative Medicine. New Delhi:
Tata McGraw‑Hill Publishing Company; 2003. p. 476.
Tariq NA. Tajul Mufradat. New Delhi: Idara Kitab Usshifa; 2010.
p. 581.
Kareem BH, Ferozuddin CH. Miftahul Khazain. New Delhi: Idara
Kitabus Shifa; YNM. p. 371.
Rehman QA, Israr Seena ba Seena. New Delhi: Idara Kitabus Shifa;
p. 94.
Anonymous. Handbook on Unani Medicines with Formulae,
Processes, Uses And Analysis. New Delhi: Asia Pacific Business
Press; YNM. p. 551.
Nadkarni KM. Indian Materia Médica. Vol. 2. Mumbai: Popular
Prakashan Private Limited; 2009. p. 158‑9.
Hafeez A. Sanatal Takless. New Delhi: Central Council of Research
in Unani Medicine; YNM. p. 87.
Bhojashettar S, Jadar PG, Rao VN. Pharmaceutical study of
Yashadabhasma. Anc Sci Life 2012;31:90‑4.
Moiz MD, Srinivas PM, Sadanandam M. Formulation and
evaluation of bilayered tablets of montelukast and levocetrizine
dihydrochloride using natural and synthetic polymers. Int J Drug
Deliv 2011;3:597‑618.
Mandal S, Rattan GN, Mulla JS, Thimmasetty J, Kaneriya A. Design
and in vitro evaluation of gastro retentive sustained release tablets
of tizanidine hydrochloride. Ind J Novel Drug Deliv 2010;2:144‑52.
Nuka R, Potu AR, Nandan R. Formulation development and
in vitro evaluation of ramipril micropellets. World J Pharm Res
;2:76‑87.
Farzana A, Halder S, Shuma ML, Rouf AS. In vitro release kinetics
study of indomethacin 12hr matrix tablet from methocel K4M CR
and methocel K15M CR. J Biomed Pharm Res 2012;1:60‑5.
Anonymous. Physicochemical Standards of Unani Formulations.
Part 4. New Delhi: Central Council of Research in Unani Medicine;
p. 142‑5.
Anonymous. Indian Pharmacopoeia. Vol 1. Ghaziabad: NISCAIR;
p. 78‑9.
Anonymous. The Ayurvedic Pharmacopoeia of India.
Part‑II (Formulations).Vol– II. New Delhi: Dept AYUSH; 2008.
p. 160.
Anonymous. Quality Control Methods for Herbal Materials.
Geneva: World Health Organization; 2011. p. 31.
Anonymous. Quality control methods for medicinal plant
materials. Geneva: World Health Organization; 1998. p. 35.
Anonymous. The Japanese Pharmacopoeia. 15th ed. Japan: Ministry
of Health, Labour and Welfare; 2006: p. 44, 68.
Aulton EM. Aultons Pharmaceutics. London: Churchill
Livingstone; 2009. p. 176‑8.
Pant KM, Gill JS, Jain SC, Joshi R, Agarkar SC, Srivastava VP.
Science and Technology. Class 8th. New Delhi: Publication
department NCERT; 2003. p. 67, 83.
Rasheed A, Marri A, Naik MM. Standardization of bhasma:
Importance and prospects. J Pharm Res 2011;4:1931‑3.
