Effect of Baliospermum montanum root extract on phagocytosis by human neutrophils
DOI:
https://doi.org/10.22377/ijgp.v2i2.41Abstract
To study the eff ect of alcohol extract of roots of Baliospermum montanum on neutrophil phagocytic function. Diff erent concentrations (25,50,100 mg/ml) of the extract of Baliospermum montanum roots were subjected to study its eff ect on diff erent in-vitro models for phagocytosis such as neutrophil locomotion, chemotaxis, immunostimulant activity on killed Candida albicans and qualitative nitroblue tetrazolium test using human neutrophils. Th is preliminary study revealed that Baliospermum montanum extract stimulated the chemotactic, phagocytic and intracellular killing potency of human neutrophils at the diff erent concentrations. From the resultsobtained it can be observed that the alcohol extract of Baliospermum montanum stimulates cell-mediated immune system by increasing neutrophil function.
Key words: Baliospermum montanum, immonostimulant, nitroblue tetrazolium test, phagocytosis
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References
Ziauddin M, Phansalkar N, Patki P, Diwanay S, Patwardhan B.
Studies on the Immunomodulatory eff ects of Ashwagandha.
J Ethanopharmacol 1996;50:69-76.
Mallurwar VR, Joharapurkar AJ, Durgakar KJ. Studies on
Immunomodulatory Activity of Mucuna prurient. Indian J Pharma
Educ Res 2006;40:205.
Patwardhan B, Kalbag D, Patki PS. Search of immunomodulatory
agents: A review. Indian Drugs 1991;28:249.
Variers PS, Arya Vaidya Sala. Indian medicinal plant: A compendium
of 500 species. Vol 1. Madras: Orient Longman Ltd; 1994. p. 240.
Chatt rjee A. Treatise on Indian Medicinal Plants. Vol 3. New Delhi:
CSIR; 1994. p. 24.
Wilkinson PC. Neutrophil leucocyte function test. In: Thomas RA,
editor. Techniques in Clinical Immunology, 2nd ed. London:
Blackwell ScientiÞ c Publication; 1981. p. 273-93.
Kulkarni SK. Handbook of Experimental Pharmacology. Delhi:
Vallabh Prakashan; 1999. p. 179-80.
Fulzele SV, Satt urwar PM, Joshi SB. Study of Immunomodulatory
activity of Haridradi Ghrita in rats. Indian J Pharmacol
;35:51-4.
Gulati K, Debnath PK, Bhatt acharya SK. Immunomodulatory
Indian medicinal plants. J Nat Remedies 2002;2:121-31.
