Bioactive phytoconstituents and plant extracts from genus Heliotropium
DOI:
https://doi.org/10.22377/ijgp.v8i4.416Abstract
Heliotropium is a genus of herbs and rarely shrubs of family Boraginaceae. Heliotropium species have been used in folk medicine for the treatment of gout, rheumatism and as antiseptic, febrifuge, cholagogue, anti‑inflammatory and healing agents. The alkaloids mainly pyrrolizidine alkaloids are the main constituents of Heliotropium species, which are responsible for several biological activities viz. anti‑tumoural, anti‑microbial, and anti‑viral effects. Phenolic compounds, terpenoids, and quinones have also been reported in this genus. The present review summarizes the various biological studies done on the extracts and bioactive phytoconstituents from the plants of the genus Heliotropium over the past few decades.Key words: Biological activities, boraginaceae, heliotropium, phytoconstituents, review
Downloads
References
The Wealth of India. National Institute of Science Communication.
Vol. 10. New Delhi: CSIR Publication; 1985. p. 28.
Rastogi RP, Mehrotra BN. Compendium of Indian Medicinal
Plants. Vol. 3. New Delhi: CSIR Publication; 1991. p. 338.
Al‑Turki TA, Omer S, Ghafoor A. Two new species of
Heliotropium L. (Boraginaceae) from Saudi Arabia. Bot J Linn Soc
;137:215‑20.
Pamplona‑Roger GD. Encyclopaedia of medicinal plants. Spain:
Editorial Safeliz; 2004. P. 713.
Reina M, Mericli A, Cabrera R, González‑Coloma A. Pyrrolizidine
alkaloids from Heliotropium bovei. Phytochemistry 1995;38:355‑8.
Singh B, Sahu PM, Jain SC, Singh S. Antineoplastic and antiviral
screening of pyrrolizidine alkaloids from Heliotropium subulatum.
Pharm Biol 2002;40:581‑6.
Singh B, Sahu PM, Singh S. Antimicrobial activity of pyrrolizidine
alkaloids from Heliotropium subulatum. Fitoterapia 2002;73:153‑5.
Wassel G, el‑menshawi B, Saeed A, Mahran G, el‑merzabani M.
Screening of selected plants for pyrrolizidine alkaloids and antitumor
activity. Pharmazie 1987;42:709.
Guntern A, Ioset JR, Queiroz EF, Foggin CM, Hostettmann K.
Quinones from Heliotropium ovalifolium. Phytochemistry
;58:631‑5.
Jain CS, Sharma R. Antimicrobial activity of triterpenoids from
Heliotropium ellipticum. Fitoterapia 1987;72:666‑8.
Medina JC, Gauze GF, Vidotti GJ, Sarragiotto MH, Basso EA,
Peixoto JL. Structural characterization of saturated pyrrolizidine
alkaloids from Heliotropium transalpinum var. transalpinum vell by
NMR spectroscopy and theoretical calculations. Tetrahedron Lett
;50:2640‑2.
Urzúa A, Modak B, Villarroel L, Torres R, Andrade L. Comparative
flavonoid composition of the resinous exudates from Heliotropium
chenopodiaceum var. chenopodiaceum and H. chenopodiaceum var.
ericoideum. Biochem Syst Ecol 1998;26:127‑30.
Reina M, Gonzalez‑Coloma A, Gutirrez C, Cabrera R,
Henriquez J, Villarroel L. Bioactive saturated pyrrolizidine
alkaloids from Heliotropium floridum. Phytochemistry
;46:845‑53.
Khan H, Khan MA, Gul F, Hussain S, Ashraf N. Anti‑inflammatory
activity of Heliotropium strigosum in animal models. Toxicol Ind
Health 2013.
Srinivas K, Rao ME, Rao SS. Anti‑inflammatory activity of
Heliotropium indicum Linn. and Leucas aspera spreng in albino rats.
Indian J Pharmacol 2003;32:37‑8.
Kulkarni‑Almeidaa A, Suthar A, Goswami A, Vishwakarma R,
Chauhan VS, Balakrishnan A, et al. Novel leads from Heliotropium
ovalifolium, 4,7,8‑trimethoxy‑naphthalene‑2‑carboxylic acid and
‑hydroxy‑5,7‑dimethoxy‑naphthalene‑2‑carbaldehyde show
specific IL‑6 inhibitory activity in THP‑1 cells and primary
humanmonocytes. Phytomedicine 2008;15:1079‑86.
Betanabhatla KS, Jasmin Sajni R, Karthik R, Raamamurthy J,
Christina AJ, Sasikumar S. Anti‑inflammatory and anti‑nociceptive
activities of Heliotropium indicum Linn. in experimental animal
models. Pharmacologyonline 2007;3:438‑45.
Mandeel Q, Taha A. Assessment of in vitro antifungal activities of
various extracts of indigenous Bahraini medicinal plants. Pharm
Biol 2005;43:164‑72.
Jain SC, Singh B, Jain R. Antimicrobial activity of triterpenoids
from Heliotropium ellipticum. Fitoterapia 2001;72:666‑8.
Singh B, Dubey MM. Estimation of triterpenoids from Heliotropium
marifolium Koen. ex Retz. In vivo and In vitro. I. Antimicrobial
screening. Phytother Res 2001;15:231‑4.
Urzúa A, EcheverrÃa J, Rezende MC, Wilkens M. Antibacterial
properties of 3 H‑Spiro[1‑benzofuran‑2,1’‑cyclohexane] derivatives
from Heliotropium filifolium. Molecules 2008;13:2385‑93.
Saeedi M, Morteza‑Semnani K. Chemical composition and
antimicrobial activity of the essential oil of Heliotropium europaeum.
Chem Nat Compd 2009;45:98‑9.
Rao PR, Nammi S, Routhu KV, Vijaya Raju AD. Antimicrobial
activity of alcoholic extract of Heliotropium indicum in vitro. Asia
Pac J Pharmacol 2006;16:121‑2.
Rao PR, Nammi S, Raju AD. Studies on the antimicrobial activity
of Heliotropium indicum Linn. J Nat Remedies 2002;2:195‑8.
Radha R, Lata T, Rajendran NN. Antimicrobial activity of
crude extracts of Heliotropium marifolium Retz. J Nat Remedies
;3:208‑11.
Jain SC, Singh B. Bioefficacy of Heliotropium ellipticum Ledeb.I.
Antimicrobial screening. Indian J Pharm Sci 1998;60:394‑6.
Jain SC, Sharma R. Antimicrobial activity of pyrrolizidine
alkaloids from Heliotropium ellipticum. Chem Pharm Bull (Tokyo)
;35:3487‑9.
Modak B, Contreras ML, Gonzalez‑Nilo F, Torres R.
Structure‑antioxidant activity relationships of flavonoids isolated
from the resinous exudate of Heliotropium sinuatum. Bioorg Med
Chem Lett 2005;15:309‑12.
Modak B, Salina M, Rodilla J, Torres R. Study of the
chemical composition of the resinous exudate isolated from
Heliotropium Sclerocarpum and evaluation of the antioxidant
properties of the phenolic compounds and the resin. Molecules
;14:4625‑33.
Murugesh K, Veerendra Y, Dash DK, Sengupta P, Maiti BC,
Maity TK. Antidiabetic, antioxidant and antihyperlipidemic status
of Heliotropium zeylanicum extract on streptozotocin‑induced
diabetes in rats. Biol Pharm Bull 2006;29:2202‑5.
Abdel‑Sattar E, Harraz FM, Al‑Ansari SM, El‑Mekkawy S,
Ichino C, Kiyohara H, et al. Antiplasmodial and antitrypanosomal
activity of plants from the kingdom of Saudi Arabia. J Nat Med
;63:232‑9.
Simonsen HT, Nordskjold JB, Smitt UW, Nyman U, Palpu P,
Joshi P, et al. In vitro screening of Indian medicinal plants for
antiplasmodial activity. J Ethnopharmacol 2001;74:195‑204.
Bero J, Ganfon H, Jonville MC, Frédérich M, Gbaguidi F,
DeMol P, et al. In vitro antiplasmodial activity of plants used in
Benin in traditional medicine to treat malaria. J Ethnopharmacol
;122:439‑44.
Moongkarndi P, Kosem N, Luanratana O, Jongsomboonkusol S,
Pongpan N. Antiproliferative activity of Thai medicinal plant
extracts on human breast adenocarcinoma cell line. Fitoterapia
;75:375‑7.
Machan T, Korth J, Liawruangrath B, Liawruangrath S, Pyne SG.
Composition and antituberculosis activity of the volatile oil of
Heliotropium indicum Linn growing in Phitsanulok, Thailand.
Flavour Fragr J 2006;21:265‑7.
Modak B, Sandino AM, Arata L, Cardenas‑Jiron G, Torres R.
Inhibitory effect of aromatic geranyl derivatives isolated from
Heliotropium filifolium on infectious pancreatic necrosis virus
replication. Vet Microbiol 2009;141:53‑8.
Adelaja AA, Ayoola MD, Otulana JO, Akinola OB, Abimbola O,
Ejiwunmi AB. Evaluation of the histo‑gastroprotective and
antimicrobial activities of Heliotropium indicum Linn (Boraginaceae).
Malays J Med Sci 2008;15:22‑30.
Valenzuela B, Imarai M, Torres R, Modak B. Immunomodulatory
effects of the aromatic geranyl derivative filifolinone tested
by the induction of cytokine expression. Dev Comp Immunol
;41:675‑82.
Rossi F, Jullian V, Pawlowiez R, Kumar‑Roiné S, Haddad M,
D a r i u s H T, et al. P r o t e c t i ve e f f e c t o f Heliotropium
foertherianum (Boraginaceae) folk remedy and its active compound,
rosmarinic acid against a Pacific ciguatoxin. J Ethnopharmacol
;30:33‑40.
Sharma SK, Goyal N. Protective effect of Heliotropium eichwaldi
against cisplatin‑induced nephrotoxicity in mice. Zhong Xi Yi Jie
He Xue Bao 2012;10:555‑60.
MacÃas FA, Simonet AM, D’Abrosca B, Maya CC, Reina M,
González‑Coloma A, et al. Megalanthine, a bioactive
sesquiterpenoid from Heliotropium megalanthum, its degradation
products and their bioactivities. J Chem Ecol 2009;35:39‑49.
Reddy JS, Rao PR, Reddy MS. Wound healing effects of
Heliotropium indicum, Plumbago zeylanicum and Acalypha indica in
rats. J Ethnopharmacol 2002;79:249‑51.
