Evaluation of antioxidant and antiparkinsonian activities of Brassica oleracea in haloperidol‐induced tardive dyskinesia

Abstract

Background: Brassica oleracea is a leafy green vegetable commonly called as cabbage. It belongs to the family Brassicaceae.Studies reveal that it is rich in flavonoids and has high antioxidant property. Aims: The present study was aimed at evaluating
antiparkinsonian activity of B. oleracea in haloperidolâ€induced tardive dyskinesia. Settings and Design: The present study was
designed for 14 days administration of the plant extract then behavioral and biochemical parameters were estimated in the rats.
Materials and Methods: B. oleracea was collected, dried in the shade, powdered, and subjected to the extraction by cold maceration using water and methanol mixture of H2O/CH3OH as a solvent. The extract was subjected to preliminary phytochemical screening. Haloperidol model was selected for screening antiparkinsonian activity, and it was administered at a dose of 1 mg/kg i.p., for 14 days. Behavioral and biochemical parameters were estimated in all the groups. Statistical Analysis Used: Statistical significance between more than two groups was tested using oneâ€way ANOVA followed by the Bonferroni’s compare all columns test using the computerâ€based fitting program. Results: In groups treated with hydroalcoholic extract of B. oleracea (250 and 500 mg/kg p.o.,) decreased the elevated levels of lipid peroxidation in the haloperidolâ€treated animals and elevated the cellular defense mechanisms such as glutathione, further suggesting the role of free radicals in the pathophysiology of the haloperidolâ€induced extrapyramidal syndrome.

Conclusion: This study reveals the use of B. oleracea in parkinsonian disease.

Key words: Behavioral parameters, biochemical parameters, Brassica oleracea, haloperidol, parkinsonian disease