Hypoglycemic effect of Lodhradi Kashaya Ghanavati in streptozotocin-induced hyperglycemia in rats

Abstract

Objective: To evaluate the hypoglycemic effect of Lodhradi Kashaya Ghanavati (LKGV) in experimental animals, LKGV was prepared, containing Lodhra (Symplocose racemosa), Haritaki (Terminalia chebula), Musta (Cyperus rotundus), and Katphal (Myrica esculanta). Materials and Methods: LKGV was prepared by the standard procedure of Kashaya Ghanavati. Hyperglycemia was induced to create an equivalent to the diabetic state by giving streptozotocin (STZ) solution (intra-peritoneal [i.p.]) 65 mg/kg, 15 min after initial administration of 120 mg/kg nicotinamide i.p. After assessment of hyperglycemia as an approximate induction of diabetes, group of animals (III, IV, and V) were treated with dose titrations using 50, 150, and 275 mg/kg of LKGV. For treatment comparison, Group VI animals were treated with a standard hypoglycemic drug, glibenclamide 10 mg/kg. Blood sugar, the level was assessed by glucometer on the 7th, 14th, 21st, and 28th day. Results: LKGV extract produced a significantly reduction of fasting blood glucose with various doses in STZ-induced diabetic rats. In a 4-week study, LKGV produced a significant reduction in blood glucose compared to glibenclamide. Conclusion: LKGV and glibenclamide significantly reduced blood sugar level. The results were more significant with successive days in this in vivo comparative study.