Anti-diabetic activity of dried extract of Tionspora cordifolia (Guduchi ghana) and honey in streptozotacin induced diabetic rats

Abstract

Objective: Guduchi (Tinospora cordifolia (Willd.) Hook.f. and Thomson) is used abundantly for Madhumeha (~diabetes mellitus) in traditional Ayurvedic medicines. The different dosage forms are mentioned in Ayurvedic classics such as Churna, Kwatha and Ghana. Hence, present study is planned to assess its anti-diabetic activity. Materials and Methods: In this study, aqueous extract of T. cordifolia was prepared by a traditional procedure of Ayurveda and assessed for its anti-diabetic activity. Diabetes was induced in Wistar strain albino rats by injecting streptozotocin in dose 40 mg/kg body weight. Aqueous extract of T. cordifolia Linn in a dose of 42.34 mg/kg was mixed with honey and administered orally. Different biochemical parameters such as blood glucose, cholesterol, triglyceride, high density lipoprotein, blood urea, creatinine, serum glutamate pyruvate transaminase, serum glutamic oxaloacetic transaminase, total protein, albumin, and globumin were assessed. Results: 24.93% reduction in blood glucose level and 28.96% reduction in glycated hemoglobin were observed in test drug treated group in comparison to diabetic control rats. Conclusion: Mild reduction of blood glucose level was observed in the analysis.