Anti-inflammatory and analgesic activity of Balanites aegyptiaca in experimental animal models
DOI:
https://doi.org/10.22377/ijgp.v2i4.8Abstract
Th e anti-infl ammatory and analgesic eff ect of ethanolic and petroleum ether extracts of Balanites aegyptiaca were evaluated in experimental animals. We have determined the anti-infl ammatory and analgesic activity of ethanolic and petroleum ether extracts of dried aerial parts of Balanites aegyptiaca by oral administration at doses of 300 and 600 mg/kg/day of body weight to healthy animals. Th e extracts were studied for their anti-infl ammatory activity in carrageenan-induced hind paw edema in rats and the paw volume was measured plethysmometrically at 0 and 3h after injection. Th e ethanolic and petroleum ether extracts were also evaluatedfor analgesic activity using Eddy’s hot plate method and tail-fl ick method in albino rats. Th e ethanolic and petroleum ether extracts of Balanites aegyptiaca, signifi cantly (P<0.05) reduced carrageenan-induced paw edema in rats and analgesic activity evidenced by increase in the reaction time by Eddy’s hot plate method and tail-fl ick method in albino mice. Th e ethanolic and petroleum ether extracts showed a greater anti-infl ammatory and analgesic eff ect comparative to the standard drugs, indomethacin and diclofenac sodium respectively. Th e present results indicated the ethanolic extract of Balanites aegyptiaca exhibited more signifi cant activity than petroleum ether in the treatment of pain and infl ammation.
Key words: Balanites aegyptiaca, indomethacin, infl ammation, pain, paw edema
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References
Hall JB, Walker DH, Balanites aegyptiaca Del. A Monograph.
School of Agriculutural and Forest Science. Banger: University of
Wales; 1991. p. 1-12.
Mohamed AM, Wolf D, Spiess WE. Recovery and characterization
of Balanites aegyptiaca Del. kernel proteins: Eff ect of defatt ing,
air classiÞ cation, wet sieving and aqueous ethanol treatment on
solubility, digestibility, amino acid composition and sapogenin
content. Nahrung 2000;44:7-12.
Iwu MM, Handbook of African Medicinal Plants. CRC Press,
Kamel MS, Ontani K, Kurokawa T, Assaf MH, El-Shannawany
MA, Ali AA, Kasai R, Ishibashi S, Tanaka O. Studies on Balanites
aegyptiaca fruits, an antidiabetic Egyptian folk medicine.
Phytochemistry 1991;31:3565-9.
Neuwinger HD, African Ethnobotony: Poisons and drugs. London:
Chapman and Hall; 1996. p. 884
Mohamed AM, Wolf W, Spiess WE. Physical, morphological and
chemical characteristics, oil recovery and fatt y acid composition
of Balanites aegyptiaca Del. kernels. Plant Foods Hum Nutr
;57:179-89.
Liu HW, Nakanishi K. The structure of Balanites: Potent
molluscides isolated from Balanites aegyptiaca. Tetrahedron
;38:513-9.
Iwu MM, Handbook of African Medicinal Plants. CRC Press, Boca
Raton, FL, Jain DC, Tripathi AK. Insect feeding detergent activity
of some saponin glycosides. Phytother Res 1991;5:139-41.
Kamel MS, Ohtani K, Kurokawa T, Assaf MH, el-Shanawany MA,
Ali AA, et al. Studies on Balanites aegyptiaca fruits: An antidiabetic
Egyptian folk medicine. Chem Pharm Bull 1991;31:1229-33.
Ibrahim AM. Anthelmintic activity of some Sudanese medicinal
plants. Phytother Res 1992;6:155-7.
Rao MV, Shah KD, Rajani M. Contraceptive effi cacy of Balanites
roxburghii pericarp extract in male mice (Mus musculus).
Phytother Res 1997;11:469-71.
Kirtikar KR, Basu BD. Indian Medicinal Plants, 3. Allahabad:
International Book Distributors; 1996. p. 1935.
Chopra RN, Nayar SL, Chopra IC. Glossary of Indian Medicinal
Plants, 1. New Delhi: CSIR Publication; 1956. p. 32.
The useful Plants of India. Vol. 213. New Delhi: CSIR Publication;
p. 270.
Sarker SD, Bartholomew B, Nash RJ. Alkaloids from Balanites
Aegyptiaca. Fitoterapia 2000;71:328-30.
Pett it GR, Doubek DL, Herald DL, Numata A, Takahasi C, Fujiki
R, et al. Isolation and structure of cytostatic saponins from
the African medicinal plant Balanites aegyptiaca. J Nat Prods
;54:1491-502.
Hosny M, Khalifa T, Calis I, Wrigth AD, Sticher O. Balanitoside:
A furostanol glycoside and 6-methyl-diosgenin from Balanites
aegyptiaca. Phytochemistry 1992;31:3565-9.
Kamel MS. A furostanol saponin from fruits of Balanites
aegyptiaca. Phytochemistry 1998;48:755-7.
Farid H, Haslinger E, Kunert O. New Glycosydes from Balanites
aegyptiaca. Helvetica Chim Acta 2002;85:1019-26.
Venkatesa Perumal R, Adiraj M, Shanmuga Pandiyan P. Synthesis,
analgesic and anti-inß ammatory evaluation of substituted 4-
piperidones. Indian Drugs 2001;38:156.
Turner RA, Screening methods in pharmacology. New York:
Academic Press; 1965. p. 100.
Brooks PM, Day RO. Nonsteroidal anti-inß ammatory drugs:
Diff erence and similarities. N Engl J Med 1991;324:1716-25.
Vane J, Booting R. Inß ammation and the mechanism of action of
anti-inß ammatory drugs. FASEB J 1987;1:89-96.
Kavimani S, Mounissamy VM, Gunasegaran R, Analgesic and antiin
ß ammatory activities of Hispidulir isolated from Helichrysum
bracteatum. Indian Drugs 2000;37:582.
Nivsarkar M, Mukherjee M, Patel M, Padh H, Bapu C. Launaea
nudicaulis leaf juice exhibits anti-inß ammatory action in acute and
chronic inß ammation models in rats. Indian Drugs 2002;39:290.
Larsen GL, Hanson PM. Mediators of inß ammation. Ann Rev
Immunol 1983;1:335-59.
Vaidya VP, Padmashali B, Vagdevi HM, Satyanarayana
ND. Antifertility Efficacy of the Plant Balanites Roxburghii
(Balanitaceae) in Female Rats. Indian J Pharma Sci 2006;347-51.
Hossinzadeh H, Ramezani M, Fedishei M, Mahmoudi M.
Antinociceptive, anti-inß ammatory and acute toxicity eff ects
of zhumeria majdae extracts in mice and rats. Phytomedicine
;9:135-41.
Ramaswamy S, Pillai NP, Gopalkrishnan V, Parmar NS, Ghosh MN.
Analgesic eff ect of O-(β-hydroxyethyl) rutoside in mice. Indian J
Exp Biol 1985;23:219.
Alcaraz MJ, Jimenez MI. Flavonoids as anti-inß ammatory agents.
Fitoterapia 1988;59:25.
