Pharmacognostical, physicochemical, and high performance thin layer chromatography evaluation of Manjisthadi kwatha in the management of psoriasis

Abstract

Background: Manjisthadi kwatha is mentioned in Ayurvedic classics as a therapeutic formulation to treat Kustha, particularly Ekkustha (psoriasis). There is about 2.5% of whole world population today who are suffering from psoriasis but management is till unsatisfactory. Manjisthadi kwatha contains manjistha (Rubia cordifolia), Katuki (Picrorhiza kurroa) and Vacha (Acorus calamus), Guduchi (Tinospora cordifolia), Nimbi (Azadirachta indica), Daruharidra (Berberis aristata) and Triphala. All ingredients of Manjisthadi kwatha having Kushthaghna property. The skin diseases are considered in the umbrella of Kushtha. Thus, it is more effective in Psoriasis internally. Materials and Methods: Manjisthadi kwatha powder was evaluated for their pharmacognostic and pharmaceutical analysis. Results: Microscopic characters were found of Manjistha, Nimbi Vacha, and Guduchi Triphla. Results obtained in pharmaceutical parameters of Manjisthadi kwatha powder such as loss on drying 15.19%, ash value 8.48%, and alcohol soluble extract 58.6% w/v are within limit mentioned by Ayurvedic pharmacopoeia of India. High performance thin layer chromatography profile of Manjisthadi kwatha powder showed similarities in number of spots. Conclusion: From the study, data developed can be espoused for laying down the standards for Manjisthadi kwatha.