Effect of trigonelline on fertility in female rats
DOI:
https://doi.org/10.22377/ijgp.v3i3.87Abstract
Antidiabetic activity of trigonelline and antifertility activity of fenugreek seeds have been reported. However, the effect of trigonelline on fertility is not reported. The aim of the study was to determine the estrogenic activity of trigonelline (75 mg/kg) as well as its effect on fertility in rats. The estrogenic activity was assessed by the vaginal cornification method. Trigonelline was administered on days 1–7 of pregnancy. The animals were anesthetized and laprotomy was carried out on day 10. The number of implantation sites was counted.The wound was sutured and animals were allowed to recover. The number of pups born after 21 days was counted. Trigonelline was
safe up to dose of 5000 mg/kg orally. Trigonelline (75 mg/kg) did not alter the estrous cycle of rats. Nonsignificant difference in the number of implants and pups born was observed in the trigonelline group compared to the control group. The lack of abortifacient activity or teratogenicity confirms the safety of trigonelline during pregnancy in rats.
Key words: Trigonelline, implantation, antidiabetic
Downloads
References
Mc Whorter LS. Biological complementary therapies: A focus on
botanical products in diabetes. Diabetes Spectrum 2001;14:199-208.
Nath D, Sethi N, Srivastava S, Jain AK. Survey on indigenous
medicinal plants used for abortion in some districts of Uttar
Pradesh†Fitoterapia 1997;68:223- 5.
El-Kamali HH, Khalid. The most common herbal remedies in
Central Sudan. Fitoterapia 1996;67:301-6.
Ziyyat A, Legssyer A, Mekhfi H, Dassouli A, Serhrouchni M,
Benjelloun W. Phytotherapy of hypertension and diabetes in
oriental Morocco. J Ethnopharmacol 1997;58:45-54.
Santillo H. Natural healing with herbs. 10th ed. USA: Hohm Press,
Prescott; 1993. p. 119-20.
Hardman R. Recent work on plant of therapeutic interest.
Phytochemistry 1969;8:1319-22.
Kassem A, Aghbari A, Habori M, Mamary M. Evaluation of
potential antifertility effect of fenugreek seeds in male and female
rabbits. Contraception 2006;73:301–6.
Kamal R, Yadav R, Sharma JD. Efficacy of the steroidal fraction of
fenugreek seed extract on fertility of male albino rats. Phytother
Res 1992;7:134-8.
Mishkinsky J, Joseph B, Sulman FG. Hypoglycaemic effect of
trigonelline. Lancet 1967;2:1311-2.
Bordia A, Verma SK. Srivastava KC. Effect of ginger (Zingiber
officinale rosc) and fenugreek (Trigonella foenum graecum L) on
blood lipids, blood sugar and platelet aggregation in patients with
coronary artery disease. Prostaglandins Leukotriens Essential Fatty
Acids 1997;56:379-84.
Vogel WV, Bernward A, Vogel WF. Drug discovery and evaluation:
Pharmacological assays. New York: Springer-Verlag Berlin
Heidelberg; 2002. p. 1159-60.
Marcondes FK, Bianchi FJ, Tanno A P, Determination of the estrous
cycle phases of rats: some helpful considerations. Braz J Biol
;62:609-14.
Bodhankar SL, Garg SK, Mathur VS. Antifertility screening of
plants. Part IX. Effect of five indigenous plants on early pregnancy
in female albino rats. Indian J Med Res 1974;62:831-7.
Hiremath SP, K. Rudresh, Badami S, Patil SP, Patil SR. Post-coital
antifertility activity of Acalypha indica L. J Ethnopharmacol
;67:253–8.
Badami S, Aneesh R, Sankar S, Sathishkumar MN, Suresh B,
Rajan S. Antifertility activity of Derris brevipes variety coriacea. J
Ethnophacol 2003;84:99-104.
Rao Udayasekhara P, Sharma RD.An evaluation of protein
quality of fenugreek seeds (Triaonella foenum araecum) and their
supplementary effects. Food Chem 1987;24:1-9.
Shani J, Goldschmied A, Joseph B, Aharonson Z, Sulaman
FG. Hypoglycemic effect of trigonella foenum graceum and
lupins tennis (Letntminosae) seed and their major alkaloids in
alloxan diabetic and normal rats. Arch Int Pharmacodyn Ther
;210:27-37.
Rao P, Sesikeran B, Srinivasa Rao P. Short term nutritional and safety
evaluation of fenugreek. Nutr Res 1996;16:1495-505.
Shah S, Bodhankar S, Bhonde R, Mohan V. Hypoglycemic
activity of the combination of active ingredients isolated from
Trigonella foenumgraecum in alloxan Induced diabetic mice.
Pharmacologyonline 2006;1:65-82.
