Antifertility activity of ethanolic extracts of Plumbago indica and Aerva lanata on albino rats
DOI:
https://doi.org/10.22377/ijgp.v3i3.90Abstract
The ethanolic extract of roots of Plumbago indica and aerial parts of Aerva lanata were evaluated for antifertility activity using antiimplantation, abortificient, and motility of rat spermatozoa (in-vitro) models. The anti-implantation effect seems to be depending on the dose as well as the initiation of treatment on specific days of pregnancy. P. indica has showed percentage pre-implantation loss of 40% and 50% against control at the doses of 200 and 400 mg/kg b/w. Percentage pregnancy failure among treated groups was 60% and 70% at the doses of 200 and 400 mg/kg b/w, whereas A. lanata has shown pre-implantation loss of 20% and 30% againstcontrol at the dose of 200 and 400 mg/kg b/w, respectively. Percentage pregnancy failure among treated groups was 30% and 40% at the dose of 200 and 400 mg/kg b/w, respectively. Both P. indica and A. lanata at a concentration of 10% have shown no motility of rat spermatozoa within 60 seconds.
Key words: Plumbago indica, Aerva lanata, anti-implantation, abortifacient, spermatozoa
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References
Dhal NK,Rout NC, Thiranavoukkarasu M. A specific case study
for birth control among the jain tribe of orissa. Ethnobotany
;12:27-8.
Afaq SH, Tajuddin S, afridi R. Some lesser know uses and
Pharmacognosy. Ethnobotany 1991;05:37.
Chandra S, Shastri MS. Chemical constituents of Aerva lanata.
Fitotherpia 1990;61:188-90.
Zapesochnaya G, Kurkin V, Okhavow V, Hiroshnikov A. Canthin-
-one and β-Carboline alkaloids from Aerva lanata. Planta Medica
;37:192-4.
Organization for Economic Co-operation and Development. Joint
meeting of the chemicals committee and the working party on
chemicals, pesticides and biotechnology. 2001.
Prathiba D, Subhash P, Aruna K. Anti-implantation and abortive
effects of Plumbago zylanica in Albino rats. Indian J Comp Anim
Physiol 1988;6:23-7.
Sur TK, Pandit S, Praminik T, Bhattacharyya D. Effect of Aegle
marmalos leaf on rat sperm motility an in-vitro study. Indian J
Pharmacol 2002;34:276-7.
Gupta RS, Batnagar AK, Joshi YC, Sharma R, Sharma A.
Suppression of fertility in male albino rats following α-Amyrin
aetate administration. Pharma Biol 2004;42:98-104.
