Aconitum: Need for sustainable exploitation (with special reference to Uttarakhand)
DOI:
https://doi.org/10.22377/ijgp.v4i4.151Abstract
Red Data Book has a long list of many endangered medicinal plants in which genus Aconitum, known as monkshood, wolfsbane, Devil's helmet or blue rocket, belonging to the family Ranunculaceae finds a key position. There are over 250 species of Aconitum.These herbaceous perennial plants are chiefly natives of the mountainous parts of the Northern Hemisphere and are characterised by significant and valuable medicinal properties. Illegal and unscientific extraction from the wild has made the important species of this genus endangered. This review focuses on the importance and medicinal uses of the genus (on the basis of literature cited from different Books and Journals and web, visits to the sites and questionnaires), which have been documented and practiced on the basis of traditional as well as scientific knowledge. The review further presents an insight on the role of conventional and modernbiotechnological methods for the conservation of the said genus, with special reference to Uttarakhand. Further, it is suggested that the policies of government agencies in coordination with the local bodies, scientists, NGOs and end-users be implemented for the sustainable conservation of Aconitum.
Key words: Aconitum, biotechnology, conservation, endangered, medicinal plants, sustainable
Downloads
References
Jain SK, Saklani A. Observations on the ethno botany of the Tons
valley region in the Uttarkashi district of the northwest Himalaya,
India. Mt Res Dev 1991;11:157-61.
Jain SK. Dictionary of Indian folk medicine and ethnobotany. New
Delhi: Deep Publications; 1991. p. 331-4.
Kala CP, Dhyani PP, Sajwan BS. Developing the medicinal plant
sector in northern India: Challenges and opportunities. J Ethnobiol
Ethnomed 2006;2:32-53.
Revitalizing traditional herbal therapy by exploring medicinal
plants: A case study of Uttaranchal State in India. Proceedings
of an International Conference on. Indigenous Knowledge:
Transforming the Academy: Penn. State University, Pennsylvania,
USA. 2004;5:15-22
Stein R. Alternative remedies gaining popularity: Majority in U.S.
try some forms, survey finds. The Washington Post Friday, May
, 2004: A01.
Singh DK, Hajara PK. Floristic Diversity. In Changing perspectives
of biodiversity channels by the plant alkaloid lappaconitine (eds
Gujral, G.S. and Sharma, V.), British Council Division, British High
Commission Publ. Wildlife Youth Services, New Delhi, 1996;23-28.
Alam G., P. van de Kop. Promoting the cultivation of medicinal
plants in Uttaranchal, India. Med. Plant Conser. 2005;11: 9-15.
Nautiyal AR, Nautiyal MC, Purohit AN, Editors. Harvesting Herbs
– 2000, Bishen Singh Mahendra Pal Singh. Dehradun, India 1997.
Tandon V. CAMP workshop–plants under threat new list forged.
Medicinal Plants Conservation. Newsl 1996; 2:12-13.
Dhar U, Manjkhola S, Joshi M, Bhatt A, Bisht AK, Joshi M. Current
status and future strategy for development of medicinal plant
sector in Uttaranchal, India. Curr Sci 2002;83:956-64.
Alam G. IPRs, access to seed and related issues: A study of the
Central and North-Eastern Himalayan region. Dehradun: Centre
for Sustainable Development; 2003.
Belt J, Lengkeek A, Vander Zant J. Cultivating a healthy enterprise:
Developing a sustainable medicinal plant chain in Uttaranchal-
India. Amsterdam: KIT Publishers; KIT Bulletin no. 350. 2003.
Available from: http://www.kit.nl/publishers/assets/images/
isbn9068328395_compleet.pdf [last cited on 2003].Alam G, Belt J.
Searching synergy: Stakeholder views on developing a sustainable
medicinal plant chain in Uttaranchal, India. Amsterdam: KIT
Publishers; KIT Bulletin no. 359. 2004. Available from:http://www.
kit.nl/net/KIT_Publicaties_output/showfile.aspx?a=tblFilesandb=
FileIDandc=FileNameandd=TheFileande=605 [last cited on 2004].
Sung Ying-hsing, T’ien Kung k’ai Wu, Sung Ying-Hsing. Published
as Chinese Technology in the seventeenth century. In: E-tu Zen
Sun, Shiou-chuan Sun, translators and annotors. Minneola. New
York: Dover Publications; 1996. p. 267.
Lane B. The encyclopaedia of forensic science. Med Hist 2004;
:53-69.
Bisset NG. Arrow poisons in China. J Ethnopharmacol 1981;4:247-
Moog FP and Karenberg A. Adverse drug reactions and
toxicological reviews. Acute aconitine poisoning. Toxicology in
the Old Testament. 2002;3:151-6.
Kitagawa I, Chen JL, Yoshimura M, Yoshikawa M. Chemical
studies on crude drug processing. II. Aconiti tuber (1). On the
constituents of chuan-wu, the dried tuber of Aconitum carmichaeli
Debeaux. Yakugaku Zasshi 1984; 104:848-57.
Bello-RamÃrez AM, Nava-Ocampo AA. The local anesthetic
activity of Aconitum alkaloids can be explained by their structural
properties: A QSAR analysis. Fundam Clin Pharmacol 2004;18:
-61.
Kim HK, Lee HW, Jeon WK. Effects of various processing methods
on the contents of alkaloids in the Cho O (Aconiti Cilliare Tuber).
Kor J Pharmacogn 2002;33:296-300.
Murayama M, Mori T, Bando H, Amiya T. Studies on the
constituents of Aconitum species. IX. The pharmacological
properties of pyro-type aconitine alkaloids, components of
the processed aconite powder 'Kako-bushi-matsu': Analgesic,
anti-inflammatory, and acute toxic activities. J Ethnopharmacol
;35:159-64.
Oyama T, Isono T, Suzuki Y, Hayakawa Y. Antinociceptive effects
of Aconiti tuber and its alkaloids. Am J Chin Med 1994;22:175-82.
Ameri A. The effects of Aconitum alkaloids on the central nervous
system. Prog Neurobiol 1998;56:211-35.
Thatte UM, Rege NN, Phatak SD, Dahanukar SA.The flip side of
Ayurveda. J Postgrad Med 1993;39:179-82.
Mitra SK, Sachan A, Udupa V. Experimental evaluation of Diarex
Vet in lactose induced diarrhea in rats. Indian Vet J 2001;78:212-6.
Jabeen N, Shawl AS, Dar GH, Sultan P. Callus induction and
organogenesis from explants of Aconitum heterophyllum-medicinal
plant. Biotechnology 2006;5:287-91.
Van de Kop P, Alam G, Bart de Steenhuijsen P. Developing a
sustainable medicinal-plant chain in India linking people, markets
and values. In: Ruben R, Slingerland M, Nijhoff H, editors.
Agro-food chains and networks for development. R. Ruben, M.
Slingerland and H. Nijhoff (eds.), Agro-food chains and networks
for development, Springer, 2006. p. 191-202.
Leaman DJ, Salvador S. An international standard for the
sustainable wild collection of medicinal and aromatic plants (ISSCMAP):
Principles, criteria, indicators and means of verification.
Draft- 2, 2005.
Joshi K, Chavan P, Warude D, Patwardhan B. Molecular markers
in herbal technology. Curr Sci 2004; 87:956-64.
Anonymous; 1. Demand study for selected medicinal plants. A
report prepared for the Ministry of Health and Family Welfare,
Govt. of India, Department of Indian System of Medicine and
Homeopathy and World Health Organization. Centre for Research
Planning and Action. New Delhi, 2002.
Maikhuri RK, Nautiyal S, Rao KS. Nanda Devi Jaimandal
aarakshit chetra (Biosphere Reserve) mein auoshadhi paadapon ki
paramparagat krishi taknique. Kosi-Katarmal, Almora: G.B. Pant
Institute of Himalayan Environment and Development; 2002. p. 24.
Schippmann U, Leaman DJ, Cunningham AB. Impact of
cultivation and gathering of medicinal plants on biodiversity:
Global trends and issues. In: Inter-Departmental Working Group
on Biological Diversity for Food and Agriculture ed. Biodiversity
and the ecosystem approach in agriculture, forestry and fisheries:
Satellite event on the occasion of the ninth regular session of the
Commission on Genetic Resources for Food and Agriculture,
Rome, 12-13 October 2002. FAO, Rome, 1-21. Available from: http://
www.ftp://ftp.fao.org/docrep/fao/005/aa010e/AA010E00.pdf [last
cited on 2009 Sep 1].
Shiva MP, Aswal S, Sharma A, Mathur P, Chandra R. Trends
of export and import of minor forest products in India, during
-71 to 1990-91.Centre of minor forest products for rural
development and environmental conservation Dehradun;
HIG 2, No. 8, Indirapuram, General Mahadev Singh Road, P.O.
Majra, Dehradun 248 171. Uttaranchal, INDIA.1996.
Samant SS, Dhar U, Palni LMs. Medicinal plants of Indian
Himalaya: Diversity, Distribution and Potential Values. Gyanodaya
Prakashan, Nainital, 1998. p. 220-32.
Hatano K, Kumara K, Shoyama Y, Mishioka I. Clonal multiplication
of Aconitum carmichaeli by tip-tissue culture technique. Planta
Medica 1998;54:152-5.
Shiping C, Shan SJ, Tanaka H, Shoyama Y. Effects of culture
temperature on microtuber formation of Aconitum carmichaelii
debx. and aconitine type Alkaloid contents. Biotronics 1998;27:
-20.
Batygina TB. Polymorphism of sexual and somatic embryos as
manifestation of their developmental parallelism under natural
conditions and in tissue culture. In: Srivastava PS, Narula A, and
Srivastava S [eds.], Plant biotechnology and molecular markers,.
Anamaya Publishers, New Delhi. 2004: 43–59
Kuniyal CP, Rajsekaran C, Prasad P, Bhadula SK. Propagation of
a threatened medicinal herb Aconitum atrox (Bruhl) Muk. through
tuber segments. Plant Genet Resour 2006;135:59-62.
Pandey H, Nandi SK, Nadeem M, Palni LM. Chemical stimulation
of seed germination in Aconitum heterophyllum Wall and A. balfouriiStapf: Important Himalayan species of medicinal value. Seed
Science and Technology. 2000;28:39-48.
Beigh SY, Nawchoo IA, Iqbal M. Cultivation and conservation of
Aconitum heterophyllum: A critically endangered medicinal herb
of the northwest Himalayas. J Herbs Spices Med Plants 2005;
:47-56.
Pandey S, Khushwaha R, Prakash O, Bhattacharya A, Ahuja PS.
Ex-situ conservation of Aconitum heterophyllum wall, an endangered
medicinal plant of the Himalaya through mass propagation and
its effect on growth and alkaloid content. Plant Genet Resour
;3:127-35.
Prasad P. Impact of cultivation on active constituents of the medicinal
plants Aconitum heterophyllum and Podophyllum hexandrum. Plant
Genet Resour Newsl 2000;124:33-5.
Gao LM, Yan LY, He HY, Wei XM. Norditerpenoid alkaloids from
Aconitum spicatum. J Integr Plant Biol 2005;48:364-9.
Tang Q, Yang C, Ye W, Liu J, Zhao S. Preparative isolation and
purification of bioactive constituents from Aconitum coreanum
by high-speed counter-current chromatography coupled with
evaporative light scattering detection. J Chromatogr 2007;11:203-7.
Lyu HN, Kwak HY, Lee DY, Kim KT, Kim SY, Baek NI. Isolation
of flavanoids from processed aconiti tuber. J Appl Biol Chem
;51:165-8.
Ahmad M, Ahmad W, Ahmad M, Zeeshan M, Obaidullah,
Shaheen F. Norditerpenoid alkaloids from the roots of Aconitum
heterophyllum wall with antibacterial activity. J Enzyme Inhib Med
Chem 2008;23:1018-22.
Nisar M, Obaidullah, Ahmad M, Wadood N, Lodhi MA, Shaheen F,
et al. New diterpenoid alkaloids from Aconitum heterophyllum wall:
Selective butyrylcholinestrase inhibitors. J Enzyme Inhib Med
Chem 2009;24:47-51.
Wang SY, Wang GK. Voltage-gated sodium channels as
primary targets of diverse lipid-soluble neurotoxins. Cell Signal
;15:151-9.
Fu M, Wu M, Qiao Y, Wang Z. Toxicological mechanisms of
Aconitum alkaloids. Pharmazie 2006;61: 735-41.
Anwar S, Ahmad B, Muhammad S, Nazar-ul-Islam and
Gul A. Biological and pharmacological properties of Aconitum
chasmanthum. J Biol Sci 2003;3(11): 989-993
Fico G, Spada A, Braca A, Agradi E, Morelli I, Tome F. RAPD
analysis and flavanoid composition of Aconitum as an aid for
taxonomic discrimination. Biochem Syst Ecol 2003;31:293-301.
Luo Y, Zhang FM, Yang QE. Phylogeny of Aconitum subgenus
Aconitum (Ranunculaceae) inferred from ITS sequences. Plant
Syst Evol 2005;252:11-25.
Mitka J, Sutkowska A, Ilnicki T, Joachimiak AJ. Reticulate evolution
of high alpine aconitum (Ranunculaceae) in the eastern Sudetes
and western Carpathians (Central Europe). Acta Biol Crac Ser
Bot 2007;49:15-26.