Management of diabetic dyslipidemia with subatmospheric dehydrated barley grass powder
DOI:
https://doi.org/10.22377/ijgp.v4i4.156Abstract
Diabetes is a chronic, potentially debilitating and often fatal disease. The prevalence of type 2 diabetes is increasing in all populations worldwide. The investigation was carried out to study the impact of barley grass powder (BGP) supplementation on the carbohydrate and lipid metabolism of stable type 2 diabetes mellitus (T2DM) subjects. A total of 59 stable type 2 diabetic subjects were enrolled in the study from pathology laboratories and divided into experimental (n=36) and control groups (n=23). BGP (1.2 g/day) in the form of capsules (n=4) was given to the experimental group subjects for a period of 60 days. Fasting blood sugar (FBS), glycated haemoglobin (HbA1c) and lipid profile levels were monitored at baseline and at 60 days. Paired t test was applied using Microsoft® Office Excel 2003. Supplementation with BGP resulted in a significant decrease in FBS, HbA1c, total cholesterol (TC), low-densitylipoprotein cholesterol (LDL-C) and non–high-density lipoprotein cholesterol (Non–HDL-C) and a significant increase in highdensity
lipoprotein cholesterol (HDL-C) levels. In conclusion, the results obtained suggest that BGP holds promise to be used as a
functional food to optimise the health of diabetic subjects.
Key words: Barley grass powder, diabetes, fasting blood sugar, lipid levels
Downloads
References
Diabetes Atlas 4th edition, International Diabetes Federation,
Available from: http://www.diabetesatlas.org [last accessed
on 2010 Feb 3].
Mohan V, Sharp PS, Cloke HR, Burrin JM, Schumer B, Kohner
EM. Serum immunoreactive insulin responses to a glucose load
in Asian Indian and European type 2 (non-insulin- dependent)
diabetic patients and control subjects. Diabetologia 1986;29:235-7.
Joshi SR. Metabolic syndrome - emerging clusters of the Indian
phenotype. J Assoc Physicians India 2003;51:445-6.
Abate N, Chandalia M, Snell PG, Grundy SM. Adipose tissue
metabolites and insulin resistance in nondiabetic Asian Indian
men. J Clin Endocrinol Metab 2004;89:2750-5.
Mohan V, Sandeep S, Deepa R, Shah B, Varghese C. Epidemiology
of type 2 diabetes: Indian scenario. Indian J Med Res 2007;125:217-
Iyer U, Joshi A, Dhruv S. Impact of Amla (Embilica Officinalis)
supplementation on the glycemic and lipidemic status of type 2
diabetic subjects. J Herbal Med Toxicol 2009;3:15-21.
Rai V, Iyer U, Mani UV. Effect of Tulasi (Ocimum sanctum) leaf
powder supplementation on blood sugar levels, serum lipids and
tissue lipids in diabetic rats. Plant Foods Hum Nutr 1997;50:9-16.
Sharma RD, Raghuram TC, Rao NS. Effect of fenugreek seeds
on blood glucose and serum lipids in type 1 diabetes. Eur J Clin
Nutr 1990;44:301-6.
Barley Grass. Available from: http://www.drugs.com/npp/barleygrass.
html [last accessed on 2010 Feb 3].
Myint PK, Luben RN, Welch AA, Bingham SA, Wareham NJ,
Khaw KT. Plasma vitamin C concentrations predict risk of incident
stroke over 10 y in 20649 participants of the European Prospective
Investigation into Cancer-Norfolk prospective population study.
Am J Clin Nutr 2008;87:64-9.
Osganian SK, Stampfer MJ, Rimm E, Spiegelman D, Hu FB,
Manson JE, et al. Vitamin C and risk of coronary heart disease in
women. J Am Coll Cardiol 2003;42:246-52.
Barley grass: How a plant remedy may offer vital protection
against heart disease, stroke and ulcerative colitis. Available
from: http://www.thehealthierlife.co.uk/natural-remedies/herbs/
barleygrass-health-benefits-00859.html [last accessed on 2003].
Osakabe N, Yamagishi M, Natsume M, Yasuda A, Osawa T.
Ingestion of proanthocyanidins derived from cacao inhibits
diabetes-induced cataract formation in rats. Exp Biol Med
(Maywood) 2004;229:33-9.
Lee YA, Cho EJ, Tanaka T, Yokozawa T. Inhibitory activities of
proanthocyanidins from persimmon against oxidative stress and
digestive enzymes related to diabetes. J Nutr Sci Vitaminol (Tokyo)
;53:287-92.
Das S, Santani DD, Dhalla NS. Experimental evidence for the
cardioprotective effects of red wine. Exp Clin Cardiol 2007;12:5-10.
Markham KR, Mitchell KA. The mis-identification of the major
antioxidant flavonoids in young barley (Hordeum vulgare) leaves.
Z Naturforsch C 2003;58:53-6.
Benedet JA, Umeda H, Shibamoto T. Antioxidant activity of
flavonoids isolated from young green barley leaves toward
biological lipid samples. J Agric Food Chem 2007;55:5499-504.
Best MM, Duncan CH, Van Loon EJ, Wathen JD. Lowering of serum
cholesterol by the administration of a plant sterol. Circulation
;10:201-6.
Katan MB, Grundy SM, Jones P, Law M, Miettinen T, Paoletti R.
Venugopal and Iyer: Barley Grass Powder and metabolic control in T2DM
Efficacy and safety of plant stanols and sterols in the management
of blood cholesterol levels. Mayo Clin Proc 2003;78:965-78.
Sheridan MJ, Cooper JN, Erario M, Cheifetz CE. Pistachio nut
consumption and serum lipid levels. J Am Coll Nutr 2007;26:141-8.
Edwards K, Kwaw I, Matud J, Kurtz I. Effect of pistachio nuts on
serum lipid levels in patients with moderate hypercholesterolemia.
J Am Coll Nutr 1999;18:229-32.
Yu YM, Wu CH, Tseng YH, Tsai CE, Chang WC. Antioxidative and
hypolipidemic effects of barley leaf essence in a rabbit model of
atherosclerosis. Jpn J Pharmacol 2002;89:142-8.
Yu YM, Chang WC, Chang CT, Hsieh CL, Tsai CE. Effects of young
barley leaf extract and antioxidative vitamins on LDL oxidation
and free radical scavenging activities in type 2 diabetes. Diabetes
Metab 2002;28:107-14.
Yu YM, Chang WC, Liu CS, Tsai CM. Effect of young barley
leaf extract and adlay on plasma lipids and LDL oxidation in
hyperlipidaemic smokers. Biol Pharm Bull 2004;27:802-5.