Protective effect of Lawsonia inermis Linn. on chronic inflammation in rats

Abstract

Background: Medicinal plants are being widely used, either as single drug or in combination in health-care delivery system. Lawsonia inermis Linn. is commonly known as henna, which is recognized in traditional system of medicine. Aim: In the present study, the anti-inflammatory and antioxidant activity was studied using an ethanolic extract of L. inermis. Materials and Methods: The bioactive compounds from L. inermis were identified by gas chromatography-mass spectrometry. The anti-inflammatory and anti-oxidants assays were followed by the standard methods. Results: The mice bioassay study was carried out by dose of 50, 100, 150, and 200 mg/kg bw, respectively. The ethanolic extracts showed the presence of Methyl salicylate (8.846), propanoic acid (9.608), ethyl (dimethyl) silyl ester 2, 1, 3-benzothiadiazole (12.258), diethyl phthalate (14.222), ethanol, 2-bromo (16.985), dibutyl phthalate (17.729), phytol (19.671), and disooctyl phthalate (23.272) all the compounds are response for anti-inflammatory activity. The extracts (100 and 200 mg/kg) showed the maximum inhibition of 39.49% and 55.98% at the end of 3 h with Carrageenan-induced in rat paw edema. A significant increase in the activities of superoxide dismutase, catalase, glutathione peroxidase, Vit-C, and Vit-E was observed in the tissue of tested groups and compared with standard and control groups. Conclusion: Through this study as a conclusion, the L. inermis possesses anti-inflammatory and antioxidant potential which may be used for therapeutic purposes mainly in the prevention of oxidative damage that occurs during inflammation.