The antidiabetic effect of leaf and stem extract of Crossandra infundibuliformis in alloxan-induced diabetic rats and diabetic nephropathy in male rats

Abstract

Background: The prevalence of diabetes is growing in the world’s population. The epidemic of disease is rising in the population of India and other countries. Many herbal plants are in use for the management of diabetes till today. They are being advantageous with the lesser side effects and high therapeutic potential than the standard antidiabetic drugs. Materials and Methods: The present research is to investigate the antidiabetic activity and antioxidant effect of ethanolic extract of Crossandra infundibuliformis leaves and stems (ECILS) in alloxaninduced diabetic rats. Diabetes is induced in the experimental animals by the administration of alloxan (150 mg/kg i.p) for a week. The total treatment period was about 30 days. Blood glucose levels were tested using standard blood glucometer. This activity also includes the estimation of biochemical parameters and in vivo antioxidant parameters such as lipid peroxidation, reduced glutathione, and catalase. Histopathological studies were performed on liver and kidney. Results: The diabetic + ECILS rats experienced a significant reduction in glucose, total cholesterol, triglycerides, and increase in high-density lipoproteins compared to disease control. Conclusion: These results demonstrate that C. infundibuliformis possess antidiabetic activity, potent antioxidant activity, and can be used in future studies for the estimation of distinct phytochemicals with the antidiabetic activity.