Antihyperlipidemic activity of ethanolic extract of Macrotyloma uniflorum (Lam.) Verdc. leaves and stems on high-fat diet-induced hyperlipidemia

Abstract

Background: Hypercholesterolemia is the state depicted by expanded greasy substances called lipids, rise in plasma total cholesterol (TC) and triglyceride (TG) levels, it is additionally called hyperlipoproteinemia. Materials and Methods: The present study was designed to investigate the hypolipidemic effect of ethanolic extract of Macrotyloma uniflorum leaves and stems (EMULS) in high-fat diet (cholesterol 2%, sodium cholate 1%, sucrose 48%, peanut oil, methionine 4%, and 47% normal laboratory feed) induced hyperlipidemia. EMULS was administered in three doses of 100 mg/kg/day p.o., 200 mg/kg/day p.o, and 400 mg/kg/day p.o each for 30 days. Results: Simultaneous administration of EMULS significantly (P < 0.01) prevents the rise in serum levels of Total Cholesterol (TCs), Triglycerides (TGs), Low Density Lipoprotein Cholesterol (LDL-C) and Very Low Density Lipoprotein Cholesterol (VLDL-C) whereas significant (p<0.05) increases in the level of High Density Lipoprotein Cholesterol (HDL-C). Conclusion: Based on the results we conclude the use of leaves and stems extract of Macrotyloma uniflorum has preventive and curative effect against hyperlipidemia.