Shankhapushpi (Convolvulus pluricaulis Choisy): Validation of the Ayurvedic therapeutic claims through contemporary studies

Authors

  • Hetal Amin
  • Rohit Sharma
  • Mahesh Vyas
  • P. K. Prajapati
  • Kartar Dhiman

DOI:

https://doi.org/10.22377/ijgp.v8i4.413

Abstract

Shankhapushpi (Convolvulus pluricaulis Choisy, CP) is an extremely versatile plant, commonly prescribed as nootropic (medhya), rejuvenator, nervine tonic in epilepsy, insanity and possesses wide range of therapeutic attributes. Since it is an essential ingredient of myriad popular Ayurvedic monoherbal or polyherbal preparations, it is commercially quite exploitable. Although CP exhibits a wide range of therapeutic attributes, only scattered information exploring the curative potential of CP is available, and there is a need to assemble it. Therefore, to revalidate the Ayurvedic therapeutic claims of Shankhapushpi in light of contemporary experimental and clinical studies, this study was carried out. Information was extracted from various Ayurvedic literature viz. Brihattrayi (Charaka Samhita, Sushruta Samhita and Ashtanga Hridaya) and Nighantu (lexicon). Online studies available on Convolvulus pluricaulis Choisy published in Pubmed, Scopemed, Pubmed Central Databases, Dhara online database and other allied databases were also
rationally reviewed and documented in the present review. The current work appears to be the first of its kind and can be considered a reference standard for future studies.
Key words: Ayurveda, Convolvulus pluricaulis, shankhapushpi

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References

Acharya YT. Charaka Samhita. 7th ed. Varanasi: Chaukhambha

Orientalia; 2002. p. 385‑542.

Yoganarasimhan SN. Medicinal Plants of India. Vol. 2. Bangalore:

Cyber Media; 2000. p. 100.

Anonymous. The Ayurvedic Pharmacopoeia of India. Vol. 2. Delhi:

Ministry of Health and Family Welfare, Department of Indian

Systems of Medicine and Homeopathy, Controller of Publications;

p. 147‑149.

Goyal PR, Singh KP. Shankhpuspi (Evolvulus alsinoides Linn) [J]

a medicinal herb. Int J Mendel 2005;22:124‑125.

Unnikrishnan E. Materia medica of the local health traditions of

Payyannur [J]. Thiruvananthapuram: Kerala Research Programme

on Local Level Development, Center for Development Studies;

p. 334.

Gupta AK, Tandon N, Sharma M. Quality standards of Indian

medicinal plants. New Delhi: Indian Council of Medical Research;

p. 126.

Acharya YT. Sushruta Samhita. 7th ed. Varanasi: Chaukhambha

Orientalia; 2002. p. 506, 186, 395, 770.

Paradakara HS. Astanga Hridaya. 4th ed. Varanasi: Chaukhambha

Sanskrita Sansthana; 2010. p. 597‑ 927.

Tripathi H. Dhanwantari Nighantu. 1st ed. Varanasi: Chowkhamba

Bharti Academy; 2008. p. 16.

Sharma PV. Kaideva Nighantu. 2nd ed. Varanasi: Chowkhamba

Orientalia; 2006. p. 622.

Tripathi I. Raja Nighantu. 4th ed. Varanasi: Chowkhamba

Krishnadas Academy; 2006. p. 58.

Ava i l a b l e f r o m : h t t p : / / l o c a l h o s t : 4 0 0 1 / e N i g h a n t u /

abhidhanamanjari/?mod=search and searchText=sha~NkhaPushpI.

[Last accessed on 2013 Jun 20].

Ava i l a b l e f r o m : h t t p : / / l o c a l h o s t : 4 0 0 1 / e ‑ N i g h a n t u /

abhidhanaratnamala/?mod=search. [Last accessed on 2013 Jun 20].

Ava i l a b l e f r o m : h t t p : / / l o c a l h o s t : 4 0 0 1 / e ‑ N i g h a n t u /

ashtanganighantu/?mod=search. [Last accessed on 2013 Jun 20].

Sharma PV. Kaideva Nighantu. 2nd ed. Varanasi: Chowkhamba

Orientalia; 2006. p. 622.

Ava i l a b l e f r o m : h t t p : / / l o c a l h o s t : 4 0 0 1 / e N i g h a n t u /

nighantushesha/?mod=search and searchText=sha ~

NkhapuShpI. [Last accessed on 2013 Jun 20].

Ava i l a b l e f r o m : h t t p : / / l o c a l h o s t : 4 0 0 1 / e N i g h a n t u /

paryayaratnamala/?mod=search and searchText=sha ~ NkhapShpI .

[Last accessed on 2013 Jun 20].

Available from: http://localhost: 4001/eNighantu/bhavaprakasha

nighantu/?mod=search and searchText=sha ~ NkhapuShpI. [Last

accessed on 2013 Jun 20].

Tripathi S. Madanpala Nighantu. 1st ed. Varanasi: Chowkhamba

Krishnadas Academy; 2009. p. 58.

Ava i l a b l e f r o m : h t t p : / / l o c a l h o s t : 4 0 0 1 / e N i g h a n t u /

m a d h a v a d r a v y a g u n a / ? m o d = s e a r c h a n d

searchText=sha~NkhapuShpI [Last accessed on 2013 Jun 20].

A v a i l a b l e f r o m : h t t p : / / l o c a l h o s t : 4 0 0 1 /

e N i g h a n t u / r a j a n i g h a n t u / ? m o d = s e a r c h a n d

searchText=sha ~ NkhapuShpI. [Last accessed on 2013 Jun 20].

Tripathi I. Rajavallabha Nighantu. 4th ed. Varanasi: Chowkhamba

Krishnadas Academy; 2006. p. 58.

Ava i l a b l e f r o m : h t t p : / / l o c a l h o s t : 4 0 0 1 / e N i g h a n t u /

shivakosha/?mod=search and searchText=sha~NkhapuShpI. [Last

accessed on 2013 Jun 20].

A v a i l a b l e f r o m : h t t p : / / l o c a l h o s t : 4 0 0 1 /

e N i g h a n t u / s i d d h a m a n t r a / ? m o d = s e a r c h a n d

searchText=sha~NkhapuShpI. [Last accessed on 2013 Jun 20].

Available from: http://localhost: 4001/eNighantu/hrdudayadipak

anighantu/?mod=search and searchText=sha~NkhapuShpI. [Last

accessed on 2013 Jun 20].

A v a i l a b l e f r o m : h t t p : / / l o c a l h o s t : 4 0 0 1 /

e N i g h a n t u / s h o d h a l a n i g h a n t u / ? m o d = s e a r c h a n d

searchText=sha ~ NkhapuShpI [Last accessed on 2013 Jun 20].

Austuin DF. Evolvulus alsinoides (Convolvulaceae): An American

herb in the Old World. J Ethnopharmacol 2008;117:185‑98.

Cramer LH. Gentianaceae. In: Dassenayake MD, Fosberg FR,

editors. A revised Handbook to the Flora of Ceylon. New Delhi:

Amarind Publishing Co; 1981. p. 55‑78.

Sa’ad F. The Convolvulus species of the Canary Islands,

the Mediterranean Region and the near and Middle East.

Mededeelingen van het Botanisch Museum en Herbarium van de

Rijks Universiteit te Utrech 1967;1:281‑288.

Dandiya PC, Chopra YM. CNS‑active drugs from plants

indigenous to India. Indian J Pharma 1970;2:67‑90.

Available from: http://www.flowersofindia.net/catalog/slides/

Shankh%20Pushpi.html. [Last accessed on 2013 Aug 24].

Dandekar. Analysis of a clinically important interaction between

phenytoin and Shankhapushpi, an Ayurvedic preparation.

J Ethnopharmacol 1992; 35 (3):285‑288.

Kapadia NS, Acharya NS, Acharya SA, Shah MB. Use of HPTLC

to establish a distinct chemical profile for Shankhpushpi and for

quantification of scopoletin in Convulvulus pluricaulis choisy and

in commercial formulations of Shankhpushpi. J Planar Chromatogr

;19:195‑9.

Zafar R, Ahmad S, Mujeeb M. Estimation of scopoletin in leaf and

leaf callus of Convolvulus microphyllus Sieb. Indian J Pharm Sci

;67:600‑3.

Asthana S, Greig NH, Holloway HW, Raffaele KC, Berardi A,

Schapiro MB, et al. Clinical pharmacokinetics of arecoline

in subjects with Alzheimer’s disease. Clin Pharmacol Ther

;60:276‑82.

Mirzaev YR, Aripova SF. Neuro and psychopharmacological

investigation of the alkaloids convolvine and atropine. Chem Nat

Comp 1998;34:56‑8.

Shah SC, Quadry SJ. A textbook of pharmacognosy. 7th ed.

New Delhi: CBS Publishers; 1990. p. 388‑389.

Deshpande SM, Srivastava DN. Chemical studies of Convulvulus

pluricaulis Choisy. J Indian Chem Soc 1969;46:759‑60.

Bisht NP, Singh R. Chemical studies of Convulvulus microphyllus

Sieb. Planta Med 1978;34:222‑3.

Basu NK, Dandiya PC. Chemical investigation of Convulvulus

pluricaulis. J Am Pharm Assoc Am Pharm Assoc 1948;37:27.

Lounasmaa M. The tropane alkaloids. In: Brossi A. The alkaloids:

Chemistry and pharmacology. New York: Academic Press; 1988.

p. 72‑74.

Prasad GC, Gupta RC, Srivastava DN, Tandon AK, Wahi RS,

Udupa KN. Effect of Shankhpushpi on experimental stress. J Res

Indian Med 1974;9:19‑27.

Singh GK, Bhandari A. Text book of pharmacognosy. New Delhi:

CBS Publishers; 2000. p. 193‑194.

Razzakov NA, Aripova SF. Confolidine, a new alkaloid from

the aerial part of Convolvulus subhirsutus. Chem Nat Comp

;40:54‑5.

Gapparov AM, Razzakov NA, Aripova SF. Alkaloids of

Convolvulus subhirsutus from Uzbekistan. Chem Nat Comp

;43:291‑2.

Gapparov AM, Aripova SF, Razzakov NA, Khuzhaev VU.

Conpropine, a new alkaloid from the aerial part of Convolvulus

subhirsutus from Uzbekistan. Chem Nat Comp 2008;44:743‑4.

Deshpande SM, Srivastava DN. Chemical examination of the fatty

acids of Convulvulus pluricaulis. Indian Oil Soap J 1969;34:217‑8.

Srivastava DN, Deshpande SM. Gas chromatographic identification

of fatty acids, fatty alcohols, and hydrocarbons of Convulvulus

pluricaulis (Choisy). J Am Oil Chem Soc 1975;52:318‑9.

Singh GK, Bhandari A. Text Book of Pharmacognosy. New Delhi:

CBS Publishers; 2000. p. 193‑194.

Patil UK, Dixit VK. Densitometric standardization of herbal medical

products containing Evolvulus alsinoides by quantification of a

marker compound. J Planar Chromatogr 2005;18:234‑9.

Nahata A, Dixit VK. Spectrofluorimetric estimation of scopoletin

in Evolvulus alsinoides Linn. and Convulvulus pluricaulis Choisy.

Indian J Pharm Sci 2008;70:834‑7.

Lounasmaa M. Tropane Alkaloids, The Alkaloids, Chemistry and

Pharmacology. In: Brossi A, editor. New York: Academic Press;

p. 68.

Lounasmaa M. The tropane alkaloids. In: Brossi A. The alkaloids:

Chemistry and pharmcology. New York: Academic Press; 1998. p. 19.

Nahata A, Patil UK, Dixit VK. Effect of Convulvulus pluricaulis

Choisy. on learning behavior and memory enhancement activity

in rodents. Nat Prod Res 2008;22:1472‑82.

Sharma VN, Barar FS, Khanna NK, Mahawar MM. Some

pharmacological actions of Convolvulus pluricaulis: An Indian

indigenous herb. Indian J Med Res 1965;53:871‑6.

Amin H, Vyas HA, Vyas MK, Harisha CR. A comparative

pharmacognostical and phytochemical study of

Shankhapushpi (Convolvulus pluricaulis) tablet with bhavana

and without bhavana. Inter J Res Ayu Pharm 2011;2:1457‑60.

Amin H, Vyas HA, Vyas MK. Philosophical and applied Ayurvedic

aspects of Mana w.s.r. to Smriti. M.D. dissertation. I.P.G.T and R.A.

Jamnagar; 2012.

Barar FS, Sharma VN. Preliminary pharmacological studies on

Convolvulus pluricaulis chois-A Indian indigenous herb. Indian

J Physiol Pharmacol 1965;9:99‑102.

Mudgal V. Studies on medicinal properties of Convolvulus

pluricaulis and Boerhaavia diffusa. Planta Med 1975;28:62‑8.

Nahata A, Patil UK, Dixit VK. Anxiolytic activity of Evolvulus

alsinoides and Convulvulus pluricaulis in rodents. Pharm Biol

;47:444‑51.

Manyam MD. Dementia in Ayurveda. J Altern Complement Med

;5:81‑8.

Dhingra D, Valecha R. Evaluation of the antidepressant like activity

of Convolvulus pluricaulis in the mouse forced swim and tail

suspension tests. Med Sci Monit 2007;13:155‑61.

Dhingra D, Valecha R. Screening for antidepressant‑like activity

of Convolvulus pluricaulis Choisy in mice. Pharmacol Online

;1:262‑78.

Pawar SA, Dhuley JN, Naik SR. Neuropharmacology of an extract

derived from Convolvulus microphyllus. Pharm Biol 2001;39:4.

Singh RH, Mehta AK. Studies on the psychotropic effect of the

Medhya Rasayana drug ‘Shankhpushpi’ (Convolvulus pluricaulis)

part 1 (Clinical Studies). J Res Ind Med Yog Homeo 1977;12:18.

Shukla SP. Anti‑anxiety agents of plant origin. Probe 1981a; 20:201.

Shukla SP. A comparative study on the barbiturate

hypnosis potentiation effect of medhya rasayana drugs

shankhapushpi (Convolvulus pluricaulis). BMEBR 1981b;1:554.

Sinha SN, Dixit VP, Madnawat AV, Sharma OP. The possible

potentiation of cognitive processing on administration of

Convolvulus microphyllus in rats. Indian Med 1989;1:1‑6.

Dandiya PC. The pharmacological basis of herbal drugs acting on

CNS. Eastern Pharm 1990;33:39‑47.

Dubey GP, Pathak SR, Gupta BS. Combined effect of Brahmi (Bacopa

monniera) and Shankhpushpi (Convolvulus pluricaulis) on

cognitive functions. Pharmacopsychoecol 1994;7:249‑51.

Sharma K, Arora V, Rana AC, Bhatnagar M. Anxiolytic effect of

convolvulus pluricaulis petals on elevated plus maze model of

anxiety in mice. J Herb Med Toxicol 2009;3:41‑6.

Sinha. The possible potentiation of cognitive processing on

administration of Convolvulus microphyllus in rats. Indian Med

;1.

Upadhyay VP. Therapeutic role of Ayurvedic herb in mental

disorders. Vedic Path 1986;69:24‑9.

Adams M, Gmunder F, Hamburger M. Plants traditionally used in

age related brain disorders‑a survey of ethnobotanical literature.

J Ethnopharmacol 2007;113:363‑81.

Ahmad S, Zafar RU, Sahid M. Anticonvulsant potential of callus

cultures of Convolvulus microphyllus Sieb. OPEM 2007;7:46‑50.

Shukla SP. Anti‑anxiety agents of plant origin. Probe 1981a; 20:201.

Chaturvedi M, Mali PC, Dixit VP. Hypolipidaemic effect

of Convolvulus microphyllus on cholesterol fed gerbils.

J Phytological Res 1997;8:153‑5.

Bhakuni RS, Tripathi AK, Shukla YN, Singh SC. Insect antifeedant

constituent from Convolvulus microphyllus (L) Sieb. Phytother

Res 1996;10:170‑1.

Gupta RC, Mudgal V. Anti‑fungal effect of Convolvulus

pluricaulis (Shankapushpi). J Res Indian Med 1974;9:67.

Panda S, Kar A. Inhibition of T3 production in levothyroxine‑treated

female mice by the root extract of Convolvulus pluricaulis. Horm

Metab Res 2001;33:16‑8.

Gupta RC, Singh PM, Prasad GC, Udupa KN. Probable mode of

action of shankhpushpi in the management of thyrotoxicosis. Anc

Sci Life 1981;1:49‑53.

Rakhit S, Basu NK. Convolvulus pluricaulis. Indian Y Pharm

;20:357‑9.

Alam MM, Siddiqui MB, Hussain W. Treatment of diabetes through

herbal drugs in rural India. Fitoterpia 1990;61:240‑2.

Singh MP, Panda H. Medicinal herbs with their formulations. 1st ed.

Delhi: Daya Publishing; 2005. p. 234.

Sairam K, Rao CV, Goel RK. Effect of Convolvulus pluricaulis

Chois on gastric ulceration and secretion in rats. Indian J Exp Biol

;39:350‑4.

Penza M, Montani C, Jeremic M, Mazzoleni G, Wendy

Hsiao WL, Marra M, et al. MAK‑4 and ‑5 supplemented diets

inhibit liver carcinogenesis in mice. BMC Complement Altern

Med 2007;7:19.

Pandit RK, Prasad GC. Role of thyrocap in the treatment of simple

diffuse goitre: A case report. J Res Edu Ind Med 1992;11:21‑4.

Rai MK. Ethnomedicinal Studies of Patalkot and Tamiya (distt.

Chhindwara): m. P.‑ plants used as tonic. Anc Sci Life 1987;7:119‑21.

Singh VK, Ali ZA, Zaidi ST, Siddiqui MK. Ethnomedicinal uses of

plants of Gonda district forests of Uttar Pradesh, India. Fitoterapia

;67:129‑39.

Husain GM, Mishra D, Singh PN, Rao CV, Kumar V.

Ethnopharmacological review of native traditional medicinal

plants for brain disorders. Phcog Rev 2007;1:20‑9.

Kumar V. Potential medicinal plants for CNS Disorders: An

overview. Phytother Res 2006;20:1023‑35.

Robinson BL, Fernald ML. Gray’s New Manual of Botany. 7th ed.

New York: American Book Co.; 1908. p. 543.

Pawar SA, Dhuley JN, Naik SR. Neuropharmacology of an

extract derived from Convulvulus microphyllus. Pharmaceut Biol

;39:253‑8.

Dandekar UP, Chandra RS, Dalvi SS, Joshi MV, Gokhale PC,

Sharma AV. Analysis of a clinically important interaction between

phenytoin and Shankhapushpi, an Ayurvedic preparation.

J Ethnopharmacol 1992;35:285‑8.

Chunekar KC. Bhavaprakasanighantu, Reprint. Varanasi:

Chowkhamba Krishnadas Academy; 1982. p. 455.

Sharma PV. Dravyaguna vijnana, Reprint. Varanasi: Chowkhamba

Krishnadas Academy; 1983. p. 10‑11.

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