Quality control evaluation of Guduchi Satva (solid aqueous extract of Tinospora cordifolia (Willd.) Miers): An herbal formulation

Authors

  • Rohit Sharma
  • Hetal Amin
  • V. J. Shukla
  • Dhiman Kartar
  • R. Galib
  • P. K. Prajapati

DOI:

https://doi.org/10.22377/ijgp.v7i3.332

Abstract

Introduction: Herbal products represent complex biological mixture and achieving a reproducible pharmaceutical quality could be a very challenging task in standardisation of herbal products. Hence, methodical approach is required for standardisation, development of sufficient quality control profile and scientific validation of plant extracts, as is done in contemporary medicine. Ayurvedic physicians
prescribe dried extract of Tinospora cordifolia (Willd.) Miers known as ‘Guduchi Satva’ in several febrile conditions. However, till today no published information is available on its analytical profile. Aims and Objectives: Present study is aimed to evaluate quality control parameters for Guduchi Satva. Materials and Methods: Fifteen batches of Guduchi Satva were prepared and findings were systematically recorded. Physicochemical parameters and qualitative tests for various functional groups, quantitative estimation of total alkaloids, fluorescence analysis, high performance thin layer chromatography (HPTLC) profile, heavy metal analysis and microbial load of Guduchi Satva were carried out. Results: The average percentage of dried Satva obtained was 3.8%. Alkaloids, carbohydrates and starch were found present in Satva. Number of peaks obtained in HPTLC also corresponds to this finding. Percentage of total
alkaloid content was 0.31%. No heavy metal and microbial load were detected in the sample. The present observation can be considered as standard for further studies on Satva.
Key words: Guduchi, quality control, Satva, Tinospora cordifolia

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References

Available from: http://www.cms.herbalgram.org/herbalgram/

issue81/article3379.html [Last accessed on 2013 Mar 20].

Kolawole OT, Ayankunle AA. Seasonal variation in the anti‑diabetic

and hypolipidemic effects of Momordica charantia fruit extract in

rats. Euro J Med Plants 2012;2:177‑85.

Available from: http://www.kr.cimap.res.in/bitstream/

/122/1/NIM%202008‑39.pdf [Last accessed on

Aug 6].

Anonymous. The Ayurvedic Formulary of India, 2nd ed. Part 1.

New Delhi: Ministry of Health and Family Welfare; 2003. p. 560.

In: Mishra B, Vaishya R, editors. Bhavprakasha Nighantu of

Bhavamishra, 10th ed. Part 1. Varanasi: Chaukhambha Sanskrit

Sansthan; 2002. p. 271.

Shastri P, editor. Sharangadhara Samhita of Sharangadhara

(Prathamakhanda), 6th ed. Ch. 1, Verse 45. Varanasi: Chaukhamba

Orientalia; 2005. p. 11.

Acharya YT. Siddha Yoga Sangraha. Urahkshatadhikara, 13th ed.

Nagpur: Baidhnath Ayurved Bhavan Ltd; 2008. p. 83‑4.

Anonymous. The Ayurvedic Pharmacopoeia of India, Vol. 1. 1st ed,

Part 1 Appendix 2.2.3‑2.2.9. New Delhi: Govt. of India, Ministry

of Health and Family Welfare; 1999. p. 213‑36.

Baxi AJ, Shukla VJ, Bhatt UB. Methods of qualitative testing of

some Ayurvedic formulations, 1st ed. Jamnagar: Gujarat Ayurved

University; 2001. p. 5‑12.

Khandelwal KR. Practical pharmacognosy techniques and

experiments, 16th ed. Pune: Nirali Prakashan; 2006. p. 149‑56.

Stephen K. Medicinal plant alkaloids: An introduction for

pharmacy students, 2nd ed. Canada: University of Toronto press;

p. 44.

Anonymous. Quality control methods for medicinal plant

materials. W.H.O., Pharm. 559, Rev. 1; 1992, p. 46‑8.

Anonymous. Quality control methods for medicinal plant

materials. W.H.O, New Delhi: A.I.T.B.S. Publishers; 2002. p. 48‑55.

Sharma R. The effect of two different dosage forms of Guduchi

i.e., Satva and Ghana W.S.R. Antihyperglycemic effect on

Madhumeha (NIDDM). M.D. Dissertation. Jamnagar: Dept. R.S.

and B.K., I.P.G.T. and R.A; 2012. p. 132‑3.

Anonymous. Quality Standards of Indian Medicinal Plants, Vol. 1.

New Delhi: ICMR; 2003. p. 212.

Acharya YT. Siddha Yoga Sangraha. Jwaradhikara, 13th ed. Nagpur:

Baidyanath Ayurveda Bhavan Ltd; 2008. p. 4.

Sharma R, Harisha CR, Galib, Patgiri BJ, Prajapati PK. Quantitative

estimation of Satva extracted from different stem sizes of

Guduchi (Tinospora cordifolia (Willd.) Miers). J Pharm Sci Inno,

;1:1:38‑40.

Navare K, editor. Nighantu Ratnakar of Panshikar VL, 1st ed. Part 1.

Delhi: Choukhambha Sanskrit Sansthan; 2011. p. 75.

Reddy KRC. Bhaishajya Kalpana Vijnanam, 2nd ed. Ch. 4. Varanasi:

Chaukhamba Samskrita Bhawan; 2005. p. 234.

Hiremath SG. A Text Book Bhaishajya Kalpana, 2nd ed. Part 1, Ch.

, Varanasi: Chaukhamba Orientalia; 2005. p. 220.

Sharma H. Rasa Yoga Sagar, 2nd ed. Varanasi: Chaukhamba

Krishnadas Academy; 2004. p. 378.

Shastri B, editor. Yogaratnakar of Anonymous, 7nd ed. Varanasi:

Choukhamba Sanskrit Sansthan; 2002. p. 118.

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