Evaluation of the antiinflammatory efficacy of Lotus pedunculatus
DOI:
https://doi.org/10.22377/ijgp.v3i2.65Abstract
The aim of this study was to investigate the antiinflammatory effect of the crude extract of Lotus pedunculatus. Aerial parts of Lotus pedunculatus were extracted by maceration with ethanol 96%. The solvent was evaporated under low pressure at 55°C to dryness, yielding crude extract. The antiinflammatory effects of Lotus pedunculatus were analyzed using carrageenan-induced mouse pleurisy. Significance was determined by analysis of variance, Dunnett’s or Student’s t-tests. Values of P < 0.05 were considered significant. The crude extract of Lotus pedunculatus inhibited leukocyte, neutrophil, myeloperoxidase, and adenosine-deaminase activities, as well as exudation, nitric oxide, interleukin-1 beta (IL-1b) and tumor necrosis factor-alpha (TNF-a) levels (P < 0.05). These resultsindicate that Lotus pedunculatus has an important antiinflammatory action and its inhibitory activity may be due to not only to the inhibition of proinflammatory mediators, but also to the inhibition of the activated leukocytes.
Key words: Air pouch, antiinflammatory activity, cytokines, enzymes, exudation, Leukocytes, Lotus pedunculatus
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